Scotland believe they can stun England at Twickenham in their next Six Nations outing and even the Welsh won't rule out a major shock.
Owen Farrell wins his 50th cap against Italy with England coach Eddie Jones forecasting his best years are still ahead of him.
Scotland sealed a first victory over Wales in ten years thanks to a vibrant second-half comeback at Murrayfield.
Standout flyhalf Johnny Sexton will start his first match of the international season in the Six Nations clash at home to France.
If Italy show anything like the same aggression on the field against England as coach Conor O'Shea, the Six Nations holders could have a tough time.
Eddie Jones has named his side for England's Six Nations game against Italy at Twickenham Stadium on Sunday.
Scotland head coach Vern Cotter has made a handful of changes to his line-up that will face Wales at Murrayfield in their Six Nations fixture.
Jonathan Sexton returned from injury to guide Ireland to a victory over France in a Six Nations international at Lansdowne Road.
Owen Farrell has insisted he has yet to feel totally relaxed in the England set-up even though he is on the brink of winning his 50th Test cap.
France head coach Guy Noves has opted to make three changes for Saturday's Six Nations clash against Ireland in Dublin.
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Jonathan Joseph has been dropped from the England side to face Italy in the Six Nations this weekend.
Italy head coach Conor O'Shea has named Michele Campagnaro and Tommaso Allan in his backline that will face England at Twickenham.
Stade Francais back rower Raphael Lakafia will replace the injured Damien Chouly ahead of France's Six Nations trip to Ireland.
Conor O'Shea says he has approached the huge challenge of being Italy rugby head coach like an alcoholic addressing his addiction.
Ireland No 8 Jamie Heaslip has signed a new contract that will see him continue to play his club rugby in Ireland until the end of the 2019 World Cup in Japan.
Georgia's hopes of playing in the Six Nations any time soon have been dashed after the tournament's chief executive insisted there was no vacancy.
George North's return from injury is the only change made by Wales for their Six Nations clash with Scotland.
Ireland stars Johnny Sexton, Rob Kearney and Conor Murray are expected to prove their fitness for the upcoming Six Nations showdown with France.
Scotland No 8 Josh Strauss will take no further part in the Six Nations after sustaining an injury to his kidney.
Anthony Watson returned to the England squad after being named in a 25-strong party for this week's training camp.
Wales scrumhalf Rhys Webb believes Greig Laidlaw's absence for the rest of the Six Nations will be "a massive loss" for Scotland.
Barrelling centre Mathieu Bastareaud is out of the Six Nations clash away to Ireland due to a head injury, France has said.
Italy head coach Conor O'Shea believes that shrinking the Six Nations would be counter productive to the growth of the game in Europe.
Scotland have suffered a major blow with the announcement that captain Greig Laidlaw will miss the rest of the Six Nations with an ankle injury.
Wales great Shane Williams says interim coach Rob Howley needs to stop picking Alex Cuthbert in "blind hope".
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