London - Two-time defending champion Novak Djokovic was sent crashing out of Wimbledon by big-serving Sam Querrey on Saturday, shattering his dreams of securing the first calendar Grand Slam in 47 years.
The world No 1, bidding for a fourth Wimbledon title and 13th major, suffered his earliest loss at a Slam since the 2009 French Open.
The 7-6 (8/6), 6-1, 3-6, 7-6 (7/5) third round defeat also ended Djokovic's open era record run of 30 successive wins at the majors and his streak of having reached 28 consecutive Grand Slam quarter-finals.
"Sam played a great match. His game was brutal and I was overpowered today," said Djokovic who added that he "wasn't 100% healthy".
"But this is not the place or time to talk about it."
It was only a second win in 10 meetings for American Querrey, the world No 41, against Djokovic and it was constructed on an epic serving performance over two days after the tie had been suspended with him two sets to the good on Friday.
The 28-year-old sent down 31 aces - 15 in the fourth set alone - and saved 14 of 17 break points while unleashing 56 winners.
His reward is a last-16 clash with 34-year-old Frenchman Nicolas Mahut.
"It's incredible, especially to do it here at Wimbledon. I'm so ecstatic right now and so happy," said Querrey.
"I played the break points really well. Got a couple of loose errors and that was it. Today he came out and got the first four games.
"He's so amazing, he's on the way to being possibly the best ever so you know he's mentally tough and going to come back."
Rain had saved 29-year-old Djokovic on Friday when the match was halted with him trailing by two sets after being comprehensively outplayed.
He had been here before. Last year, he was two sets to love down to Kevin Anderson in the fourth round before staging a thrilling comeback.
On the resumption Saturday, the US, Australian and French Open champion broke for 2-0 in the third set and backed it up with a service hold.
More rain returned after just 17 minutes of play with the top seed 4-0 ahead.
After two hours of shelter, Djokovic returned to grab a 5-0 lead and survive a blip before claiming the set, 6-3.
Querrey had to save three break points in the opening game of the fourth set and three more in the third for a 2-1 lead, his thunderous serve providing a welcome escape route.
Djokovic had two more chances to break in the fifth game before finally breaking through at the 12th time of asking for a 5-4 lead.
But he couldn't convert with the American hitting straight back for 5-5 and holding for 6-5 when, yet again, the rain returned to cause another suspension, this time lasting an hour.
Djokovic served to take the set into the tie-break and was ahead at 2/0 and 4/3 but the resolute Querrey still went to two match points.
The top seed saved the first, but ballooned a forehand wide and his fate was sealed to leave Rod Laver in 1969 remaining as the last man to sweep all four majors in the same year.
Wimbledon results on Saturday, the fifth day of the 2016 championships (x denotes seeded player):
Sam Querrey (USA x28) bt Novak Djokovic (SRB x1) 7-6 (8/6), 6-1, 3-6, 7-6 (7/5)
Nicolas Mahut (FRA) bt Pierre-Hugues Herbert (FRA) 7-6 (7/5), 6-4, 3-6, 6-3
David Goffin (BEL x11) bt Denis Istomin (UZB) 6-4, 6-3, 2-6, 6-1
Milos Raonic (CAN x6) bt Jack Sock (USA x27) 7-6 (7/2), 6-4, 7-6 (7/1)
Steve Johnson (USA) bt Grigor Dimitrov (BUL) 6-7 (6/8), 7-6 (7/3), 6-4, 6-2
Marin Cilic (CRO x9) bt Lukas Lacko (SVK) 6-3, 6-3, 6-4
Kei Nishikori (JPN x5) bt Andrey Kuznetsov (RUS) 7-5, 6-3, 7-5
Bernard Tomic (AUS x19) bt Roberto Bautista (ESP x14) 6-2, 6-4, 6-4
Andy Murray (GBR x2) bt John Millman (AUS) 6-3, 7-5, 6-2
Alexander Zverev (GER x24) bt Mikhail Youzhny (RUS) 6-4, 3-6, 6-0, 4-6, 6-2
Agnieszka Radwanska (POL x3) bt Katerina Siniakov (CZE) 6-3, 6-1
Dominika Cibulkova (SVK x19) bt Eugnie Bouchard (CAN) 6-4, 6-3
Simona Halep (ROM x5) bt Kiki Bertens (NED x26) 6-4, 6-3
Madison Keys (USA x9) bt Alize Cornet (FRA) 6-4, 5-7, 6-2
Misaki Doi (JPN) bt Anna-Lena Friedsam (GER) 7-6 (7/1), 6-3
Angelique Kerber (GER) bt Carina Witthoeft (GER) 7-6 (13/11), 6-1
Yaroslava Shvedova (KAZ) bt Sabine Lisicki (GER) 7-6 (7/2), 6-1
Lucie Safarova (CZE x28) bt Jana Cepelov (SVK) 4-6, 6-1, 12-10
Sloane Stephens (USA x18) bt Mandy Minella (LUX) 3-6, 7-6 (8/6), 8-6
Timea Bacsinszky (SUI x11) bt Monica Niculescu (ROM) 4-6, 6-2, 6-1
Ekaterina Makarova (RUS) bt Petra Kvitova (CZE x10) 7-5, 7-6 (7/5)