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London - Swiss fifth seed and French Open runner-up Stan Wawrinka was knocked out of Wimbledon in the first round by Russia's Daniil Medvedev on Monday, losing 6-4, 3-6, 6-4, 6-1.
World number 49 Medvedev, making his Wimbledon debut, goes on to face Belgian qualifier Ruben Bemelmans for a place in the last 32.
It was Wawrinka's sixth first round loss at the All England Club, although his efforts were hampered by a left knee injury which required an ice pack at the changeovers.
It also meant that 33-year-old Wawrinka's hopes of becoming just the sixth man to complete the career Grand Slam were ended for another year.
Having lost in the first round at Queen's Club last month, Wawrinka's grass-court campaign amounted to two matches and two defeats.
For 21-year-old Medvedev, it was a first win at the Grand Slam level, coming on the back of an impressive grass court season.
He made the semi-finals in Eastbourne last week where it took Novak Djokovic to stop him, as well as the quarter-finals at 's-Hertogenbosch and Queen's.
"A year ago I was ranked 250. If someone told me in one year I would win on Centre Court I would tell you you are joking," said Medvedev, who kissed the grass of Centre Court to celebrate his victory.
Wimbledon results on Monday, the first day of the 2017 championships at the All England Club (x denotes seeding):
Men
1st rd
Andy Murray (GBR x1) bt Alexander Bublik (KAZ) 6-1, 6-4, 6-2
Dustin Brown (GER) bt Joo Sousa (POR) 3-6, 7-6 (7/5), 6-4, 6-4
Fabio Fognini (ITA x28) bt Dmitry Tursunov (RUS) 6-1, 6-3, 6-3
Pierre-Hugues Herbert (FRA) bt Nick Kyrgios (AUS x20) 6-3, 6-4 -- retired
Benot Paire (FRA) bt Rogrio Dutra Silva (BRA) 6-4, 3-6, 7-6 (12/10), 6-4
Jerzy Janowicz (POL) bt Denis Shapovalov (CAN) 6-4, 3-6, 6-3, 7-6 (7/2)
Lucas Pouille (FRA x14) bt Malek Jaziri (TUN) 6-7 (5/7), 6-4, 6-4, 7-6 (7/2)
Jo-Wilfried Tsonga (FRA x12) bt Cameron Norrie (GBR) 6-3, 6-2, 6-2
Simone Bolelli (ITA) bt Lu Yen-Hsun (TPE) 6-3, 1-6, 6-3, 6-4
Nikoloz Basilashvili (GEO) bt Carlos Berlocq (ARG) 6-4, 7-6 (7/3), 6-1
Sam Querrey (USA x24) bt Thomas Fabbiano (ITA) 7-6 (7/5), 7-5, 6-2
Kevin Anderson (RSA) bt Fernando Verdasco (ESP x31) 2-6, 7-6 (7/5), 7-6 (10/8), 6-3
Andreas Seppi (ITA) bt Norbert Gombos (SVK) 6-2, 3-6, 6-2, 6-1
Ruben Bemelmans (BEL) bt Tommy Haas (GER) 6-2, 3-6, 6-3, 7-5
Daniil Medvedev (RUS) bt Stan Wawrinka (SUI x5) 6-4, 3-6, 6-4, 6-1
Rafael Nadal (ESP x4) bt John Millman (AUS) 6-1, 6-3, 6-2
Donald Young (USA) bt Denis Istomin (UZB) 5-7, 6-4, 6-4, 4-2 -- retired
Thiago Monteiro (BRA) bt Andrew Whittington (AUS) 4-6, 6-3, 7-6 (7/4), 7-6 (7/5)
Karen Khachanov (RUS x30) bt Andrey Kuznetsov (RUS) 7-6 (7/4), 2-6, 6-3, 1-6, 6-2
Damir Dzumhur (BIH) bt Renzo Olivo (ARG) 6-2, 6-0, 6-1
Luks Rosol (CZE) bt Henri Laaksonen (SUI) 4-6, 7-5, 6-3, 6-4
Gilles Muller (LUX x16) bt Mrton Fucsovics (HUN) 7-5, 6-4, 6-2
Kei Nishikori (JPN x9) bt Marco Cecchinato (ITA) 6-2, 6-2, 6-0
Sergiy Stakhovsky (UKR) bt Julien Benneteau (FRA) 6-3, 7-6 (10/8), 2-6, 6-2
Peter Gojowczyk (GER) bt Marius Copil (ROM) 7-6 (7/5), 2-6, 6-3, 6-1
Roberto Bautista (ESP x18) bt Andreas Haider-Maurer (AUT) 6-3, 6-1, 6-2
Florian Mayer (GER) bt Viktor Troicki (SRB) 6-1 -- retired
Marin Cilic (CRO x7) bt Philipp Kohlschreiber (GER) 6-4, 6-2, 6-3
Women
1st rd
Dominika Cibulkova (SVK x8) bt Andrea Petkovic (GER) 6-3, 3-6, 9-7
Jennifer Brady (USA) bt Danka Kovinic (MNE) 6-3, 6-1
Irina Begu (ROM) bt Naomi Broady (GBR) 6-4, 6-2
Barbora Strcov (CZE x22) bt Vernica Cepede (PAR) 6-3, 6-3
Naomi Osaka (JPN) bt Sara Sorribes (ESP) 6-3, 7-6 (7/3)
Wang Qiang (CHN) bt Kai-Chen Chang (TPE) 6-3, 6-4
Venus Williams (USA x10) bt Elise Mertens (BEL) 7-6 (9/7), 6-4
Franoise Abanda (CAN) bt Kurumi Nara (JPN) 6-2, 6-4
Camila Giorgi (ITA) bt Alize Cornet (FRA) 5-7, 6-4, 6-4
Madison Keys (USA x17) bt Nao Hibino (JPN) 6-4, 6-2
Carina Witthoeft (GER) bt Mirjana Lucic-Baroni (CRO x26) 6-3, 5-7, 8-6
Aryna Sabalenka (BLR) bt Irina Khromacheva (RUS) 6-3, 6-4
Francesca Schiavone (ITA) bt Mandy Minella (LUX) 6-1, 6-1
Elina Svitolina (UKR x4) bt Ashleigh Barty (AUS) 7-5, 7-6 (10/8)
Johanna Konta (GBR x6) bt Hsieh Su-Wei (TPE) 6-2, 6-2
Maria Sakkari (GRE) bt Katerina Siniakov (CZE) 6-3, 6-4
Kristna Plskov (CZE) bt Roberta Vinci (ITA x31) 7-6 (8/6), 6-2
Caroline Garcia (FRA x21) bt Jana Cepelov (SVK) 6-1, 6-1
Ana Bogdan (ROM) bt Duan Ying-Ying (CHN) 6-4, 6-2
Madison Brengle (USA) bt Richel Hogenkamp (NED) 6-3, 6-3
Petra Kvitova (CZE x11) bt Johanna Larsson (SWE) 6-3, 6-4
Heather Watson (GBR) bt Maryna Zanevska (BEL) 6-1, 7-6 (7/5)
Anastasija Sevastova (LAT) bt Yulia Putintseva (KAZ) 6-1, 7-6 (7/3)
Beatriz Haddad Maia (BRA) bt Laura Robson (GBR) 6-4, 6-2
Simona Halep (ROM x2) bt Marina Erakovic (NZL) 6-4, 6-1
