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READ: Odds stacked heavily against Anderson
South Africa's own Kevin Anderson takes on eight-time champion, Swiss maestro Roger Federer, in the first match on Court 1, while over on Centre Court, Serbia's Novak Djokovic faces Japan's Kei Nishikori.
Both matches start at 14:00 SA time.
Following those matches, Canada's Milos Raonic takes on American John Isner (Court 1), while world No 1, Spain's Rafal Nadal, and Argentinian giant Juan Martin del Potro will close proceedings on Centre Court.
Wimbledon results on Wednesday, the ninth day of the 2018 championships (x denotes seeded player):
Kevin Anderson (RSA x8) bt Roger Federer (SUI x1) 2-6, 6-7 (5/7), 7-5, 6-4, 13-11
Novak Djokovic (SRB x12) bt Kei Nishikori (JPN x24) 6-3, 3-6, 6-2, 6-2