London - Venus Williams suffered a stunning Wimbledon exit as the five-time champion became the latest star to crash out in a 6-2, 6-7 (5/7), 8-6 defeat against Kiki Bertens on Friday.
After reaching the final last year and the semi-finals in 2016, Venus was expected to mount another strong challenge for the Wimbledon title.
But instead the 38-year-old was worn down by Dutch 20th seed Bertens in a dramatic third round clash lasting two hours and 40 minutes in sweltering heat on Court One.
Venus, seeded ninth, joined Petra Kvitova, Maria Sharapova, Caroline Wozniacki and Sloane Stephens as the most high-profile casualties of Wimbledon's year of the giant-killers in the women's singles.
For the first time in the Open era, fewer than four top 10 seeds have made the Wimbledon fourth round.
Only world No 1 Simona Halep and former US Open finalist Karolina Pliskova remain, with Venus's sister Serena, seeded 25th after her return from pregnancy, installed as the title favourite.
Bertens faces Czech seventh seed Pliskova or Romanian world No 28 Mihaela Buzarnescu for a place in the quarter-finals.
"It means a lot. I still really can't believe it. It was such a tough match and such a big fight so I'm really happy that I won this one," Bertens said.
"It was really tough because I played her in Miami, I had a few match points there and I lost so that was going into my mind sometimes.
"But I was just like, 'OK, keep on going for it, you're in Wimbledon in the third round, never reached the fourth round so you've nothing to lose and just go for your shots."
Denied in the Wimbledon final by Garbine Muguruza 12 months ago, Venus has failed in her bid to win an eighth Grand Slam crown 10 years after her last major triumph.
Last year, Venus made two Grand Slam finals and one semi-final, but this term she has failed to get past the third round in any of the three majors.
Eighteen years after winning her first Wimbledon title, Venus was the oldest woman in the tournament, so perhaps it wasn't surprising the 26-year-old Bertens had the greater staying power.
For Williams, losing the first set was nothing unusual at Wimbledon this year after she battled back to win her opening two matches following the same deficit.
But neither of those escape acts came after such a one-sided set.
Bertens, who reached the French Open semi-finals in 2016, had never before been past the Wimbledon third round.
She squandered a chance to serve for the match in the second set, then couldn't convert two match points before finally falling to the turf in jubilation when Venus sent a backhand wide.
Wimbledon results on Friday, the fifth day of the 2018 championships (x denotes seeded player):
Alexander Zverev (GER x4) bt Taylor Fritz (USA) 6-4, 5-7, 6-7 (0/7), 6-1, 6-2
Gael Monfils (FRA) bt Sam Querrey (USA x11) 5-7, 6-4, 6-4, 6-2
Kevin Anderson (RSA x8) bt Philipp Kohlschreiber (GER x25) 6-3, 7-5, 7-5
Kiki Bertens (NED x20) bt Venus Williams (USA x9) 6-2, 6-7 (5/7), 8-6
Julia Goerges (GER x13) bt Barbora Zhlavov Strcov (CZE x23) 7-6 (7/3), 3-6, 10-8
Donna Vekic (CRO) bt Yanina Wickmayer (BEL) 7-6 (7/2), 6-1
Evgeniya Rodina (RUS) bt Madison Keys (USA x10) 7-5, 5-7, 6-4
Camila Giorgi (ITA) bt Katerina Siniakov (CZE) 3-6, 7-6 (8/6), 6-2
Ekaterina Makarova (RUS) bt Lucie Safarova (CZE) 4-6, 6-4, 6-1