London - Naomi Osaka, Alexander Zverev and Stefanos Tsitsipas crashed out of Wimbledon on a black Monday for the stars at the All England Club.
Japanese superstar slumped to a 7-6 (7/4), 6-2 defeat to 39th-ranked Yulia Putintseva of Kazakhstan who had defeated the world number two on grass in Birmingham two weeks ago.
She was joined at the exit door by German sixth seed Zverev and Tsitsipas, the seventh seed, both players tipped as potential champions this year.
US Open and Australian Open winner Osaka is the first top-two seed to lose in the first round since Martina Hingis in 2001.
The defeat follows her third round exit at the French Open.
"Can we stop now? I think I am going to cry," she told reporters as she made a quick exit from her post-match news conference.
Osaka has yet to make a final since her Australian Open win in January.
"There are answers to questions that you guys ask that I still haven't figured out yet," she admitted.
Zverev, 22, lost 4-6, 6-3, 6-2, 7-5 to Czech qualifier Jiri Vesely, the world number 124.
"Everything outside the court affects you, I won't get into details now, but the last couple of days have been very rough for me," said Zverev who has never got beyond the last 16.
Just 15 minutes after Zverev's defeat, 20-year-old Tsitsipas lost 6-4, 3-6, 6-4, 6-7 (8/10), 6-3 to world number 89 Thomas Fabbiano of Italy.
Tsitsipas had reached the semi-finals of the Australian Open in January and the last-16 at Roland Garros as well as the fourth round at Wimbledon last year.
"If I won today I would not have deserved it. It should have been over in three sets," said Tsitsipas.
"I feel devastated."
Canadian 18-year-old Felix Auger-Aliassime kept 'NextGen' hopes alive by beating Canadian compatriot Vasek Pospisil 5-7, 6-2, 6-4, 6-3.
Victory made the 19th seed the first player born in the 2000s to win a match at Wimbledon.
Defending champion Novak Djokovic got his campaign for a fifth Wimbledon title off to a winning start with newly-hired coaching team recruit, and 2001 winner, Goran Ivanisevic helping steer the ship.
Djokovic, chasing a fifth title at the All England Club, saw off 35-year-old Philipp Kohlschreiber of Germany 6-3, 7-5, 6-3.
If his victory was routine, there was nothing predictable about Djokovic's decision to bring Ivanisevic into his inner sanctum over the weekend.
"I have always looked up to Goran. When he won here in 2001, I feel I was part of that as he had trained in Germany at the same base as me when I was 13-14," said Djokovic.
"I feel as if I contributed to his victory," joked Djokovic who next faces Denis Kudla of the United States.
Fourth seed Kevin Anderson, runner-up to Djokovic in 2018, eased into the second round beating Pierre-Hugues Herbert of France 6-3, 6-4, 6-2.
Anderson will now play Serbia's Janko Tipsarevic who registered his first win at the tournament in seven years when he defeated Japan's Yoshihito Nishioka 6-4, 6-7 (2/7), 6-2, 5-7, 6-2.
In the women's event, third seed Karolina Pliskova made it through, beating China's Zhu Lin 6-2, 7-6 (7/4).
Czech former world number one Pliskova, fresh from winning the Eastbourne title, has never got past the fourth round at Wimbledon.
Slovakia's Magdalena Rybarikova, a semi-finalist in 2017, put out 10th seeded Aryna Sabalenka of Belarus 6-2, 6-4 in just 70 minutes.
Also heading home was French Open runner-up and 16th seed Marketa Vondrousova.
The 19-year-old Czech lost 6-4, 6-4 to America's Madison Brengle who is used to pulling off Wimbledon shocks having knocked out two-time winner Petra Kvitova in 2017.
Former French Open champion Simona Halep overcame an injury scare to make the second round with a 6-4, 7-5 win over Aliaksandra Sasnovich.
Halep, seeded seven and a semi-finalist in 2014, needed to have her left ankle strapped after a worrying fall on Court One.
Later Monday, five-time champion Venus Williams, now 39, who first played at the All England Club in 1997, takes on 15-year-old compatriot Cori Gauff.
Gauff is the youngest player ever to have qualified for Wimbledon and comes into the tournament ranked at 313 in the world.
Wimbledon results on Monday (x denotes seeding):
Men
1st round
Novak Djokovic (SRB x1) bt Philipp Kohlschreiber (GER) 6-3, 7-5, 6-3
Denis Kudla (USA) bt Malek Jaziri (TUN) 6-4, 6-1, 6-3
Leonardo Mayer (ARG) bt Ernests Gulbis (LAT) 6-1, 7-6 (14/12), 6-2
Hubert Hurkacz (POL) bt Dusan Lajovic (SRB x32) 6-3, 4-6, 6-4, 6-4
Félix Auger-Aliassime (CAN x19) bt Vasek Pospisil (CAN) 5-7, 6-2, 6-4, 6-3
Daniil Medvedev (RUS x11) bt Paolo Lorenzi (ITA) 6-3, 7-6 (7/2), 7-6 (7/2)
Alexei Popyrin (AUS) bt Pablo Carreño-Busta (ESP) 7-6 (7/2), 7-5, 6-2
Jérémy Chardy (FRA) bt Martin Kližan (SVK) 3-6, 6-0, 6-3, 6-4
Fernando Verdasco (ESP) bt Kamil Majchrzak (POL) 6-4, 6-4, 6-4
Ivo Karlovic (CRO) bt Andrea Arnaboldi (ITA) 6-4, 6-4, 7-6 (7/4)
Thomas Fabbiano (ITA) bt Stefanos Tsitsipas (GRE x7) 6-4, 3-6, 6-4, 6-7 (8/10), 6-3
Kevin Anderson (RSA x4) bt Pierre-Hugues Herbert (FRA) 6-3, 6-4, 6-2
Janko Tipsarevic (SRB) bt Yoshihito Nishioka (JPN) 6-4, 6-7 (2/7), 6-2, 5-7, 6-2
Andreas Seppi (ITA) bt Nicolás Jarry (CHI) 6-3, 6-7 (8/10), 6-1, 6-2
Guido Pella (ARG x26) bt Marius Copil (ROU) 7-6 (13/11), 5-7, 6-3, 6-4
Stan Wawrinka (SUI x22) bt Ruben Bemelmans (BEL) 6-3, 6-2, 6-2
Reilly Opelka (USA) bt Cedrik-Marcel Stebe (GER) 6-3, 7-6 (7/4), 6-1
Robin Haase (NED) bt Jozef Kovalík (SVK) 6-1, 6-3, 6-1
Milos Raonic (CAN x15) bt Prajnesh Gunneswaran (IND) 7-6 (7/1), 6-4, 6-2
Karen Khachanov (RUS x10) bt Soonwoo Kwon (KOR) 7-6 (8/6), 6-4, 4-6, 7-5
Feliciano Lopez (ESP) bt Marcos Giron (USA) 6-4, 6-2, 6-4
Steve Darcis (BEL) bt Mischa Zverev (GER) 6-2, 6-4, 6-4
Roberto Bautista Agut (ESP x23) bt Peter Gojowczyk (GER) 6-3, 6-2, 6-3
Benoît Paire (FRA x28) bt Juan Ignacio Londero (ARG) 4-6, 6-4, 6-4, 7-6 (7/4)
Pablo Cuevas (URU) bt Damir Džumhur (BIH) 4-6, 7-6 (10/8), 2-6, 6-4, 6-2
Jirí Veselý (CZE) bt Alexander Zverev (GER x6) 4-6, 6-3, 6-2, 7-5
Women
1st round
Elina Svitolina (UKR x8) bt Daria Gavrilova (AUS) 7-5, 6-0
Margarita Gasparyan (RUS) bt Anna-Lena Friedsam (GER) 6-4, 6-4
Marie Bouzkova (CZE) bt Mona Barthel (GER) 6-3, 6-3
Maria Sakkari (GRE x31) bt Bernarda Pera (USA) 7-6 (7/4), 6-3
Petra Martic (CRO x24) bt Jennifer Brady (USA) 3-6, 6-3, 6-4
Anastasia Potapova (RUS) bt Jil Teichmann (SUI) 2-6, 6-4, 6-1
Danielle Collins (USA) bt Zarina Diyas (KAZ) 6-3, 7-5
Anastasija Sevastova (LAT x12) bt Kristie Ahn (USA) 6-3, 6-4
Madison Brengle (USA) bt Markéta Vondroušová (CZE x16) 6-4, 6-4
Karolína Muchová (CZE) bt Aleksandra Krunic (SRB) 7-5, 6-2
Heather Watson (GBR) bt Caty McNally (USA) 7-6 (7/3), 6-2
Anett Kontaveit (EST x20) bt Shelby Rogers (USA) 6-0, 3-6, 6-4
Kirsten Flipkens (BEL) bt Dalila Jakupovic (SLO) 6-1, 6-3
Monica Puig (PUR) bt Anna Karolína Schmiedlová (SVK) 5-7, 6-4, 7-5
Karolina Pliskova (CZE x3) bt Zhu Lin (CHN) 6-2, 7-6 (7/4)
Simona Halep (ROM x7) bt Aliaksandra Sasnovich (BLR) 6-4, 7-5
Mihaela Buzarnescu (ROU) bt Jessica Pegula (USA) 6-4, 6-4
Ajla Tomljanovic (AUS) bt Darya Kasatkina (RUS x29) 6-3, 6-1
Madison Keys (USA x17) bt Luksika Kumkhum (THA) 6-3, 6-2
Polona Hercog (SLO) bt Viktoria Kuzmova (SVK) 4-6, 7-6 (7/5), 7-5
Magdalena Rybarikova (SVK) bt Aryna Sabalenka (BLR x10) 6-2, 6-4
Veronika Kudermetova (RUS) bt Ysaline Bonaventure (BEL) 6-2, 6-4
Yanina Wickmayer (BEL) bt Rebecca Peterson (SWE) 6-4, 6-3
Sofia Kenin (USA x27) bt Astra Sharma (AUS) 6-4, 6-2
Dayana Yastremska (UKR) bt Camila Giorgi (ITA) 6-3, 6-3
Viktorija Golubic (SUI) bt Iga Swiatek (POL) 6-2, 7-6 (7/3)
Yulia Putintseva (KAZ) bt Naomi Osaka (JPN x2) 7-6 (7/4), 6-2