London - Rafael Nadal suffered fresh Wimbledon misery on Monday as the two-time champion crashed to a stunning 6-3, 6-4, 3-6, 4-6, 15-13 fourth round defeat against Luxembourg's Gilles Muller.
Just weeks after winning his 10th French Open title, Nadal was condemned to his fifth exit before the quarter-finals in his last five visits to Wimbledon.
"It was not my best match against a very uncomfortable opponent," said Nadal, the 2008 and 2010 champion.
"Well done to him. He played great, especially in the fifth set but I fought to the last ball."
The 31-year-old Spaniard, finally worn down by Muller after four hours and 48 minutes on Court One, hasn't made the quarter-finals since 2011.
"Tired," was 34-year-old Muller's response after the thrilling encounter, which had the knock-on effect of pushing Novak Djokovic's last 16 match against Adrian Mannarino back to Tuesday.
World number two Nadal converted just two of 16 break points, while Muller fired 30 aces and 95 winners.
Muller, seeded 16th, will make his first Wimbledon quarter-final appearance against former US Open champion Marin Cilic.
In a pulsating final set, which stretched to 95 minutes, Nadal saved two match points in 10th game and two more in the 20th.
In between, Muller had to fight off a break point in the 13th game and four more in the 19th.
Amidst relentless tension, even a mundane women's scarf played a part when it was used to block out the evening sunlight reflecting off the stands into Nadal's eyes.
Nadal was always chasing the score and he finally cracked in the 18th game of the decider when he went long with a return.
"It was a long match. I did really well in the first two sets then Rafa stepped it up and in the end it was just a big battle. I had match points and didn't make them so it was getting really tough," said Muller after a second career win over Nadal, 12 years after his first which also came at Wimbledon.
"I was kind of feeling that it was going to be over pretty soon. I said just give it a shot, go 100 percent and a great feeling to be winning that match.
"I didn't feel like was playing bad in the third and fourth sets. I just told myself keep it up and if it's not happening, he's just too good.
"I started serving a bit better and then at the end, it's just a matter of a few points here and there. It's tough to say exactly what made the difference.
"I haven't really realised what just happened. It's a great feeling. I was worried it was going to be over pretty soon.
"I was already thinking about coming back the next day and finishing the match. I'm just glad it's over and I'm in the quarter-finals."
Muller was watched by a VIP fan in the shape of Prince Felix of Luxembourg, second in line to the country's throne.
"I heard he was going to come. We know each other. He's a big tennis fan. The whole family likes tennis," said Muller.
Wimbledon results on Monday, the seventh day of the 2017 championships at the All England Club (x denotes seeding):
Andy Murray (GBR x1) bt Benoit Paire (FRA) 7-6 (7/1), 6-4, 6-4
Sam Querrey (USA x24) bt Kevin Anderson (RSA) 5-7, 7-6 (7/5), 6-3, 6-7 (11/13), 6-3
Marin Cilic (CRO x7) bt Roberto Bautista Agut (ESP x18) 6-2, 6-2, 6-2
Milos Raonic (CAN x6) bt Alexander Zverev (GER x10) 4-6, 7-5, 4-6, 7-5, 6-1
Roger Federer (SUI x3) bt Grigor Dimitrov (BUL x13) 6-4, 6-2, 6-4
Tomas Berdych (CZE x11) bt Dominic Thiem (AUT x8) 6-3, 6-7 (1/7), 6-3, 3-6, 6-3
Garbie Muguruza (ESP x14) bt Angelique Kerber (GER x1) 4-6, 6-4, 6-4
Svetlana Kuznetsova (RUS x7) bt Agnieszka Radwanska (POL x9) 6-2, 6-4
Magdalena Rybarikova (SVK) bt Petra Martic (CRO) 6-4, 2-6, 6-3
Coco Vandeweghe (USA x24) bt Caroline Wozniacki (DEN x5) 7-6 (7/4), 6-4
Venus Williams (USA x10) bt Ana Konjuh (CRO x27) 6-3, 6-2
Jelena Ostapenko (LAT x13) bt Elina Svitolina (UKR x4) 6-3, 7-6 (8/6)
Johanna Konta (GBR x6) bt Caroline Garcia (FRA x21) 7-6 (7/3), 4-6, 6-4
Simona Halep (ROM x2) bt Victoria Azarenka (BLR) 7-6 (7/3), 6-2