London - Eight-time Wimbledon singles champion Roger Federer posted yet more landmarks on Saturday as all the main contenders encountered few problems in reaching the last 16.
Federer registered a record 350th win in Grand Slam matches in his 7-5, 6-2, 7-6 (7/4) victory over Lucas Pouille of France and in the process reached the fourth round for an unprecedented 17th time.
"It's a nice number to achieve. I've enjoyed my time at the Slams," said Federer of his Grand Slam record.
"It's been nice winning that much."
Earlier, his great rival and two-time Wimbledon champion Rafael Nadal had a much more enjoyable experience than his previous match as he eased into the last 16 with a 6-2, 6-3, 6-2 romp over French veteran Jo-Wilfried Tsonga.
The ease with which Nadal made the fourth round for the ninth time was replicated on the women's side by Ashleigh Barty, who will be breaking new ground in appearing in the last 16 for the first time.
Seven-time women's champion Serena Williams is also into the second week for the 16th time.
Nadal, who embraced Tsonga fondly at the end in stark contrast to the chilly handshake he had with fiery Australian Nick Kyrgios in the previous round, said he was delighted with the manner of his victory.
"I was very happy," said Nadal. "I played a great match from the beginning to the end.
"Jo is one of those players you don't want to face early but today was my day."
Andy Murray's hopes of men's doubles glory ended early as he and French partner Pierre-Hugues Herbert went out in the second round.
However, he was to end the day on a celebratory note as his star partnership with Williams eased into the second round of the mixed doubles beating Germany's Andreas Mies and Alexa Guarachi of Chile 6-4, 6-1.
Neither would claim who was running the show.
Serena said there was no "I in team" while Murray said they were both used to being told what to do.
"I said to Serena before the match we are the younger siblings so we are used to being bossed by our older brother and sister," said Murray
On the women's side Barty and Williams could meet in a blockbuster quarter-final if they win their last 16 matches on 'Manic Monday'.
Two of the top 10 seeds did bow out, Dutch fourth seed Kiki Bertens and American ninth seed Sloane Stephens losing to Czech Republic's Barbora Strycova and Britain's French Open semi-finalist Johanna Konta respectively.
While Barty will be in new territory playing singles at Wimbledon in the second week for the first time, for Williams it is the 16th.
Barty overwhelmed British wild card Harriet Dart 6-1, 6-1 while 37-year-old, seven-time champion Williams produced her most convincing display in dispensing with German Julia Goerges 6-3, 6-4.
Barty, bidding to become the first Australian Wimbledon women's champion since Evonne Goolagong Cawley won her second title in 1980, will play unseeded American Alison Riske for a place in the last eight.
She is also the first Australian woman to make the second week since 2010.
"Incredible it is a first for me (to be in the last 16), new territory for me."
Williams goes on to face Spain's Carla Suarez Navarro for a place in the quarter-finals.
Eleventh seed Williams, who defeated Goerges in last year's semi-finals, is bidding to equal Margaret Court's all-time record of 24 Grand Slam titles.
"It's been an arduous year for me, so every match I'm hoping to improve tons," said Williams, who had a knee problem which affected her season.
There was no fairytale win in the mixed doubles, though, for the star of the championships Coco Gauff.
The 15-year-old American - who has wowed the crowds in reaching the last 16 of the women's singles - and her British partner Jay Clarke lost 6-1, 6-4, in the first round to Robert Lindstedt and Jelena Ostapenko.
Wimbledon results on Saturday (x denotes seeding):
Sam Querrey (USA) bt John Millman (AUS) 7-6 (7/3), 7-6 (10/8), 6-3
Tennys Sandgren (USA) bt Fabio Fognini (ITA x12) 6-3, 7-6 (14/12), 6-3
Joao Sousa (POR) bt Daniel Evans (GBR) 4-6, 6-4, 7-5, 4-6, 6-4
Rafael Nadal (ESP x3) bt Jo-Wilfried Tsonga (FRA) 6-2, 6-3, 6-2
Kei Nishikori (JPN x8) bt Steve Johnson (USA) 6-4, 6-3, 6-2
Mikhail Kukushkin (KAZ) bt Jan-Lennard Struff (GER x33) 6-3, 7-6 (7/5), 4-6, 7-5
Matteo Berrettini (ITA x17) bt Diego Schwartzman (ARG x24) 6-7 (5/7), 7-6 (7/2), 4-6, 7-6 (7/5), 6-3
Roger Federer (SUI x2) bt Lucas Pouille (FRA x27) 7-5, 6-2, 7-6 (7/4)
Ashleigh Barty (AUS x1) bt Harriet Dart (GBR) 6-1, 6-1
Alison Riske (USA) bt Belinda Bencic (SUI x13) 4-6, 6-4, 6-4
Serena Williams (USA x11) bt Julia Goerges (GER x18) 6-3, 6-4
Carla Suarez Navarro (ESP x30) bt Lauren Davis (USA) 6-3, 6-3
Barbora Strycova (CZE) bt Kiki Bertens (NED x4) 7-5, 6-1
Elise Mertens (BEL x21) bt Qiang Wang (CHN x15) 6-2, 6-7 (9/11), 6-4
Johanna Konta (GBR x19) bt Sloane Stephens (USA x9) 3-6, 6-4, 6-1
Petra Kvitova (CZE x6) bt Magda Linette (POL) 6-3, 6-2
Wimbledon men's singles last 16 line-up (x denotes seeded player):
Novak Djokovic (SRB x1) v Ugo Humbert (FRA)
David Goffin (BEL x21) v Fernando Verdasco (ESP)
Guido Pella (ARG x26) v Milos Raonic (CAN x15)
Roberto Bautista Agut (ESP x23) Benoit Paire (FRA x28)
Sam Querrey (USA) v Tennys Sandgren (USA)
Joao Sousa (POR) v Rafael Nadal (ESP x3)
Kei Nishikori (JPN x8) v Mikhail Kukushkin (KAZ)
Matteo Berrettini (ITA x17) v Roger Federer (SUI x2)
Wimbledon women's singles last 16 line-up (x denotes seeded player):
Ashleigh Barty (AUS x1) v Alison Riske (USA)
Serena Williams (USA x11) v Carla Suarez Navarro (ESP x30)
Elise Mertens (BEL x21) v Barbora Strycova (CZE)
Petra Kvitova (CZE x6) v Johanna Konta (GBR x19)
Elina Svitolina (UKR x8) v Petra Martic (CRO x24)
Karolina Muchova (CZE) v Karolina Pliskova (CZE x3)
Simona Halep (ROM x7) v Coco Gauff (USA)
Zhang Shuai (CHN) v Dayana Yastremska (UKR)