Murray and Williams' Wimbledon dream over

London - Andy Murray and Serena Williams' mixed doubles dream team came unstuck at Wimbledon on Wednesday when the star pairing were knocked out by the top seeds.

The pair lost 6-3, 4-6, 6-2 to Bruno Soares of Brazil and Nicole Melichar of the United States, who progress to the quarter-finals.

The third round match was played out on the 4,000-seater Court Two sunken bowl -- a rare appearance outside the Centre Court and Court One big show courts for the likes of multiple former champions Murray and Williams.

British home favourite Murray, a former world number one, is easing his way back into tennis via the doubles after undergoing radical hip resurfacing surgery.

Wimbledon results on Wednesday (x denotes seeding):

Men

Quarter finals

Novak Djokovic (SRB x1) bt David Goffin (BEL x21) 6-4, 6-0, 6-2

Roberto Bautista Agut (ESP x23) bt Guido Pella (ARG x26) 7-5, 6-4, 3-6, 6-3

Rafael Nadal (ESP x3) bt Sam Querrey (USA) 7-5, 6-2, 6-2

Roger Federer (SUI x2) bt Kei Nishikori (JPN x8) 4-6, 6-1, 6-4, 6-4