London - Spanish seventh seed David Ferrer failed in his bid to reach an 18th consecutive third round at a Grand Slam when he was knocked out of Wimbledon by Russian qualifier Andrey Kuznetsov on Wednesday.
The 32-year-old Ferrer last failed to reach the third round at a major at the 2010 Australian Open.
But Kuznetsov, the world number 118, claimed a famous 6-7 (5/7), 6-0, 3-6, 6-3, 6-2 win to reach the third round at Wimbledon for the first time.
Ferrer had come into the tournament still suffering the after-effects of the illness which forced him out of the 's-Hertogenbosch grasscourt warm-up in the Netherlands last week.
"Well of course I am sad. It's a disappointment, but it's not the end of the world."
Twice a quarter-finalist at Wimbledon, Ferrer had reached the round of 16 at the last 16 Slams, and the quarter-finals at the last 10.
Wednesday's win was a first top 10 triumph for Kuznetsov, the 2009 junior champion at Wimbledon.
Wimbledon results on Wednesday, the third day of the 2014 championships at the All England Club (x denotes seeded player):
Men
Second round
Novak Djokovic (SRB x1) bt Radek Stepanek (CZE) 6-4, 6-3, 6-7 (5/7), 7-6 (7/5)
Gilles Simon (FRA) bt Robin Haase (NED) 7-6 (7/1), 6-4, 6-4
Jimmy Wang (TPE) bt Mikhail Youzhny (RUS x17) 7-6 (7/1), 6-2, 6-7 (5/7), 6-3
Sergiy Stakhovsky (UKR) bt Ernests Gulbis (LAT x12) 6-4, 6-3, 7-6 (7/5)
Jrmy Chardy (FRA) bt Marinko Matosevic (AUS) 6-7 (5/7), 7-6 (9/7), 7-6 (11/9), 4-6, 7-5
Marin Cilic (CRO x26) bt Andreas Haider-Maurer (AUT) 3-6, 6-1, 6-4, 6-4
Tomas Berdych (CZE x6) bt Bernard Tomic (AUS) 4-6, 7-6 (7/5), 7-6 (7/3), 6-1
Andy Murray (GBR x3) bt Blaz Rola (SLO) 6-1, 6-1, 6-0
Roberto Bautista (ESP x27) bt Jan Hernych (CZE) 7-5, 4-6, 6-2, 6-2
Kevin Anderson (RSA x20) bt Edouard Roger-Vasselin (FRA) 7-6 (7/0), 1-6, 6-3, 6-4
Fabio Fognini (ITA x16) bt Tim Petz (GER) 2-6, 6-4, 7-6 (8/6), 6-3
Grigor Dimitrov (BUL x11) bt Luke Saville (AUS) 6-3, 6-2, 6-4
Aleksandr Dolgopolov (UKR x21) bt Benjamin Becker (GER) 6-7 (4/7), 7-6 (7/0), 6-3, 6-4
Leonardo Mayer (ARG) bt Marcos Baghdatis (CYP) 7-6 (7/4), 4-6, 6-1, 6-4
Andrey Kuznetsov (RUS) bt David Ferrer (ESP x7) 6-7 (5/7), 6-0, 3-6, 6-3, 6-2
Suspended due to darkness:
Sam Querrey (USA) level with Jo-Wilfried Tsonga (FRA x14) 6-4, 6-7 (2/7), 7-6 (7/4), 3-6, 9-9
Women
Second round
Bojana Jovanovski (SRB) bt Victoria Azarenka (BLR x8) 6-3, 3-6, 7-5
Tereza Smitkov (CZE) bt Coco Vandeweghe (USA) 6-3, 7-6 (7/4)
Lucie Safarova (CZE x23) bt Polona Hercog (SLO) 7-6 (9/7), 7-5
Dominika Cibulkova (SVK x10) bt Alison Van Uytvanck (BEL) 3-6, 6-3, 8-6
Caroline Garcia (FRA) bt Varvara Lepchenko (USA) 7-5, 6-3
Ekaterina Makarova (RUS x22) bt Misaki Doi (JPN) 7-5, 6-4
Michelle Larcher de Brito (POR) bt Jarmila Gajdosova (AUS) 6-3, 4-6, 6-3
Agnieszka Radwanska (POL x4) bt Casey Dellacqua (AUS) 6-4, 6-0
Petra Kvitova (CZE x6) bt Mona Barthel (GER) 6-2, 6-0
Venus Williams (USA x30) bt Kurumi Nara (JPN) 7-6 (7/4), 6-1
Peng Shuai (CHN) bt Maria Kirilenko (RUS) 6-0, 6-3
Lauren Davis (USA) bt Flavia Pennetta (ITA x12) 6-4, 7-6 (7/4)
Caroline Wozniacki (DEN x16) bt Naomi Broady (GBR) 6-3, 6-2
Ana Konjuh (CRO) bt Yanina Wickmayer (BEL) 3-6, 6-2, 6-2
Ana Konjuh (CRO) bt Yanina Wickmayer (BEL) 3-6, 6-2, 6-2
Barbora Zhlavov Strcov (CZE) bt Elena Vesnina (RUS x32) 6-4, 6-2
Li Na (CHN x2) bt Yvonne Meusburger (AUT) 6-2, 6-2
First round
Vera Zvonareva (RUS) bt Tara Moore (GBR) 6-4, 6-7 (3/7), 9-7
Zarina Diyas (KAZ) bt Kristina Mladenovic (FRA) 7-6 (7/4), 6-4