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The 34-year-old Australian is planning on retiring at the Australian Open next January.
A former world No 1, Hewitt has won just one match this year and has dropped to 117th in the rankings.
"Thx @Wimbledon for the Wildcard," Hewitt said on Twitter. "An honour to play 1 more time at such a great place! Great memories. #OneLastTime."
Other men who were given wild card singles entries on Wednesday include Nicolas Mahut of France and three British players.
Mahut won his third career title last week at the Topshelf Open on grass. The Frenchman is also famous for losing the longest match in tennis history in the first round of Wimbledon in 2010, an 11-hour, 5-minute marathon that ended 70-68 in the fifth set against John Isner.
Two British players - Naomi Broady and Johanna Konta - were granted invitations for the women's singles, as were Estonia's Anett Kontaveit and Latvia's Jelena Ostapenko.
More wild cards will be announced before play begins on June 29.
