Miami - World No 1 Simona Halep tumbled out of the Miami Open on Saturday, falling 3-6, 6-2, 6-3 to Poland's Agnieszka Radwanska.
The third round defeat comes a week after Romania's Halep was toppled in the semi-finals at Indian Wells by Japan's Naomi Osaka, who went on to win the title in the California desert.
Halep's exit leaves the women's field in the hardcourt tournament without its top two seeds, after second-seeded Australian Open champion Caroline Wozniacki lost to Monica Puig on Friday.
Despite the defeat, Halep is assured of retaining the number one spot when the rankings are updated at the end of the tournament.
Radwanska, the 2012 Miami champion, hadn't posted back-to-back match victories since January.
She'll face either 20th-seeded Anastasija Sevastova of Latvia or former world number one Victoria Azarenka of Belarus for a place in the quarter-finals.
Azarenka is unseeded this year as she vies to get her career on track after taking time off to have a baby.
Results at the WTA and ATP Miami Open tournament on Saturday (x denotes seeding):
Men
Second round
Tomas Berdych (CZE x10) bt Yoshihito Nishioka (JPN) 6-1, 6-4
Frances Tiafoe (USA) bt Kyle Edmund (GBR x21) 7-6 (7/4), 4-6, 7-6 (7/5)
Alexander Zverev (GER x4) bt Daniil Medvedev (RUS) 6-4, 1-6, 7-6 (7/5)
David Ferrer (ESP x28) bt Evgeny Donskoy (RUS) 6-2, 6-2
Denis Shapovalov (CAN) bt Damir Dzumhur (BIH x24) 6-1, 7-5
Borna Coric (CRO x29) bt Leonardo Mayer (ARG) 6-7 (5/7), 6-3, 6-4
Women
Third round
Agnieszka Radwanska (POL x30) bt Simona Halep (ROM x1) 3-6, 6-2, 6-3
Zarina Diyas (KAZ) bt Carina Witthoeft (GER) 4-6, 7-5, 6-0
Karolina Pliskova (CZE x5) bt Hsieh Su-Wei (TPE) 6-4, 1-6, 7-6 (7/4)