Sydney - Spain's world number three Garbine Muguruza was forced out of the Sydney International with an injury following her win over Kiki Bertens on Wednesday.
A week after retiring from the Brisbane International with cramps, leading Australian Open contender Muguruza had an early medical timeout for a thigh injury before beating Bertens 6-3, 7-6 (8/6).
But the win came at a cost. The Wimbledon champion later announced she would be pulling out of the tournament, handing Australian Daria Gavrilova direct passage to the semi-finals.
Muguruza's decision comes less than a week out from the Australian Open in Melbourne.
"I am disappointed but I have talked to the WTA doctors and my team after the match today and following their recommendation, I have to withdraw from the tournament," Muguruza said.
"I have felt pain in my right adductor since I started practising here.
"Yesterday I felt better and wanted to play. However, during the match today the pain has been there all the time but I wanted to compete."
Muguruza was leading 2-1 in the opening set when she sought a medical time-out.
She showed few ill-effects upon her return to the court, reeling off six of the next eight games to take a commanding lead against the 32nd-ranked Dutchwoman.
The Spanish top seed claimed the first set before needing a tiebreaker to see off her opponent.
Gavrilova downed Samantha Stosur in their all-Australian second round night match 6-4, 6-2 and will benefit from Muguruza's setback to advance to the last four.
Poland's Agnieszka Radwanska reached her fifth Sydney quarter-final with a straight-sets win over American qualifier Catherine Bellis 7-6 (7/4), 6-0.
Radwanska will play Italian qualifier Camila Giorgi, who eliminated two-time Wimbledon champion Petra Kvitova 7-6 (9/7), 6-2.
In the men's event, Spanish top seed Albert Ramos-Vinolas was knocked out by Italy's Paolo Lorenzi 6-3, 7-5.
The Spanish world number 22 needed treatment for a leg problem early in the second set but continued playing, without success, as Lorenzi moved into the quarter-finals.
The Italian will play Russian qualifier Daniil Medvedev for a semi-final berth.
French pair Adrian Mannarino and Benoit Paire progressed to the last eight with victories on Wednesday.
Fifth seed Mannarino downed Lithuania's Ricardas Berankis 6-2, 6-1, while Paire needed three sets to get past Argentina's Leonardo Mayer 6-2, 3-6, 6-1.
Rising Australian star Alex de Minaur has a quarter-final with Spaniard Feliciano Lopez after his opponent Damir Dzumhur - 30th in the world rankings - retired when the youngster was leading 6-2 3-0.
Lopez took out Argentine third seed Diego Schwartzman 6-3, 7-6 (7/1).
Results from the ATP/WTA Sydney International on Wednesday (x denotes seed):
Paolo Lorenzi (ITA) bt Albert Ramos-Vinolas (ESP x1) 6-3, 7-5
Adrian Mannarino (FRA x5) bt Ricardas Berankis (LTU) 6-2, 6-1
Benoit Paire (FRA) bt Leonardo Mayer (ARG) 6-2, 3-6, 6-1
Fabio Fognini (ITA x4) bt Alexandr Dolgopolov (UKR) 3-6, 6-3, 6-4
Daniil Medvedev (RUS) bt Jared Donaldson (USA) 6-3, 4-6, 7-5
Alex de Minaur (AUS) bt Damir Dzumhur (BIH) 6-2, 3-0 ret.
Feliciano Lopez (ESP) bt Diego Schwartzman (ARG x3) 6-3, 7-6 (7/1)
Agnieszka Radwanska (POL) bt Catherine Bellis (USA) 7-6 (7/4), 6-0
Garbine Muguruza (ESP x1) bt Kiki Bertens (NED) 6-3, 7-6 (8/6)
Camila Giorgi (ITA) bt Petra Kvitova (CZE) 7-6 (9/7), 6-2
Daria Gavrilova (AUS) bt Samantha Stosur (AUS) 6-4, 6-2