New York - World No 1 Serena Williams, trying to complete a calendar-year Grand Slam at the US Open, could face sister Venus in the quarter-finals and Maria Sharapova in the semi-finals.
The draw conducted on Thursday at Arthur Ashe Stadium set the path for Williams to try and make more tennis history as she seeks a 22nd career Grand Slam singles crown to match the Open Era record total of Steffi Graf.
Williams will open against Russia's Vitalia Diatchenko and could face Croatian Mirjana Lucic-Baroni in the second round.
Poland's Agnieszka Radwanska, seeded 15th, is a possible round of 16 foe for Williams, with her elder sister or Swiss teen Belinda Bencic - who beat Williams in the Toronto semi-finals earlier this month - possible quarter-final opponents.
Sharapova is in Williams' half of the draw as well with Romania's second-seeded Simona Halep or Danish fourth seed Caroline Wozniacki her highest-rated potential finals foes.