Cape Town - South Africa's Lloyd Harris is out of the French Open after he was beaten in the second round by 13th-seeded Borna Coric of Croatia.
Coric beat Harris in straight sets, winning 6-2, 6-3, 7-6 (7/2) in a match that lasted a little over two hours.
Earlier this week, Harris beat Lukas Rosol in a five-set first round encounter.
On Tuesday, South Africa's only other entrant at Roland Garros, Raven Klaasen and his partner Michael Venus were knocked out in the first round of the doubles competition.
The sixth-seeded pair were eliminated when they lost to Marius Copil (Belgium) and Rohan Bopanna (India) in straight sets 6-3, 7-6 (7/4).
Results from the fifth day of the French Open on Thursday (x denotes seeding):
Men
Second round
Novak Djokovic (SRB x1) bt Henri Laaksonen (SUI) 6-1, 6-4, 6-3
Salvatore Caruso (ITA) bt Gilles Simon (FRA x26) 6-1, 6-2, 6-4
Jan-Lennard Struff (GER) bt Radu Albot (MDA) 7-6 (7/2), 7-6 (7/3), 6-7 (4/7), 6-2
Borna Coric (CRO x13) bt Lloyd Harris (RSA) 6-2, 6-3, 7-6 (7/2)
Fabio Fognini (ITA x9) bt Federico Del Bonis (ARG) 6-4, 3-6, 6-3, 6-3
Roberto Bautista Agut (ESP x18) bt Taylor Fritz (USA) 6-2, 6-3, 6-2
Dusan Lajovic (SRB x30) bt Elliot Benchetrit (FRA) 6-3, 6-3, 6-4
Alexander Zverev (GER x5) bt Mikael Ymer (SWE) 6-1, 6-3, 7-6 (7/3)
Dominic Thiem (AUT x4) bt Alexander Bublik (KAZ) 6-3, 6-7 (6/8), 6-3, 7-5
Pablo Cuevas (URU) bt Kyle Edmund (GBR x28) 7-6 (7/3), 6-3, 2-1 - retired
Antoine Hoang (FRA) bt Fernando Verdasco (ESP x23) 6-4, 3-6, 7-6 (7/5), 7-5
Gael Monfils (FRA x14) bt Adrian Mannarino (FRA) 6-3, 6-4, 6-4
Karen Khachanov (RUS x10) bt Grégoire Barrère (FRA) 6-3, 7-6 (8/6), 0-6, 7-5
Jordan Thompson (AUS) bt Ivo Karlovic (CRO) 6-3, 6-4, 6-7 (2/7), 6-3
Juan Martín Del Potro (ARG x8) bt Yoshihito Nishioka (JPN) 5-7, 6-4, 6-2, 6-7 (5/7), 6-2
Leonardo Mayer (ARG) bt Diego Schwartzman (ARG x17) 4-6, 6-3, 6-4, 7-5
Women
Second round
Naomi Osaka (JPN x1) bt Victoria Azarenka (BLR) 4-6, 7-5, 6-3
Katerina Siniaková (CZE) bt Maria Sakkari (GRE x29) 7-6 (7/5), 6-7 (8/10), 6-3
Anna Blinkova (RUS) bt Caroline Garcia (FRA x24) 1-6, 6-4, 6-4
Serena Williams (USA x10) bt Kurumi Nara (JPN) 6-3, 6-2
Andrea Petkovic (GER) bt Su-Wei Hsieh (TPE x25) 4-6, 6-3, 8-6
Ashleigh Barty (AUS x8) bt Danielle Collins (USA) 7-5, 6-1
Simona Halep (ROM x3) bt Magda Linette (POL) 6-4, 5-7, 6-3
Mónica Puig (PUR) bt Darya Kasatkina (RUS x21) 6-3, 6-1
Iga Swiatek (POL) bt Wang Qiang (CHN x16) 6-3, 6-0
Amanda Anisimova (USA) bt Aryna Sabalenka (BLR x11) 6-4, 6-2
Irina-Camelia Begu (ROM) bt Karolína Muchová (CZE) 1-6, 6-3, 6-4
Ekaterina Alexandrova (RUS) bt Samantha Stosur (AUS) 3-6, 6-1, 6-4
Aliona Bolsova (ESP) bt Sorana Cirstea (ROM) 7-6 (7/5), 7-6 (7/3)
Belinda Bencic (SUI x15) bt Laura Siegemund (GER) 4-6, 6-4, 6-4