Paris - Fifth seed Juan Martin del Potro brushed aside John Isner 6-4, 6-4, 6-4 to reach the French Open quarter-finals for the first time since 2012 on Monday.
The Argentinian produced an impressive display on Court Suzanne Lenglen, firing 25 winners and making just 14 unforced errors against the American ninth seed.
The 29-year-old Del Potro was knocked out in the third round at Roland Garros last year after missing the previous four tournaments in Paris through injury.
He will face either fellow former US Open champion and third seed Marin Cilic or fiery Italian Fabio Fognini in the last eight.
Results from day nine of the French Open at Roland Garros on Monday (x denotes seeding):
Rafael Nadal (ESP x1) bt Maximilian Marterer (GER) 6-3, 6-2, 7-6 (7/4)
Diego Schwartzman (ARG x11) bt Kevin Anderson (RSA x6) 1-6, 2-6, 7-5, 7-6 (7/0), 6-2
Marin Cilic (CRO x3) bt Fabio Fognini (ITA x18) 6-4, 6-1, 3-6, 6-7 (4/7), 6-3
Juan Martín Del Potro (ARG x5) bt John Isner (USA x9) 6-4, 6-4, 6-4
Simona Halep (ROM x1) bt Elise Mertens (BEL x16) 6-2, 6-1
Angelique Kerber (GER x12) bt Caroline Garcia (FRA x7) 6-2, 6-3
Garbiñe Muguruza (ESP x3) bt Lesia Tsurenko (UKR) 2-0 - retired
Maria Sharapova (RUS x28) bt Serena Williams (USA) - walkover
Daria Kasatkina (RUS x14) bt Caroline Wozniacki (DEN x2) 7-6 (7/5), 6-3