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Paris - Dutch fourth seed Kiki Bertens, one of the favourites for the French Open, retired from her second round match through illness on Wednesday.
The 27-year-old, a semi-finalist in 2016, was trailing Slovakia's Viktoria Kuzmova 3-1, 40-15 when she called for the doctor, complaining she was suffering from "shaking and no energy".
Bertens was seen as a potential champion in Paris having won the Madrid title without dropping a set, the first woman to achieve the feat.
Kuzmova goes on to face either Britain's Johanna Konta or Lauren Davis of the United States for a place in the last 16.
World number 46 Kuzmova had already defeated Bertens in Dubai this year before the Dutchwoman gained revenge in Miami.
She has now made the last 32 of a Grand Slam for the first time.
Results from the fourth day of the French Open on Wednesday (x denotes seeding):
Men
2nd round
Stefanos Tsitsipas (GRE x6) bt Hugo Dellien (BOL) 4-6, 6-0, 6-3, 7-5
Filip Krajinovic (SRB) bt Roberto Carballes Baena (ESP) 6-4, 6-4, 6-7 (1/7), 3-6, 8-6
Stan Wawrinka (SUI x24) bt Christian Garin (CHI) 6-1, 6-4, 6-0
Grigor Dimitrov (BUL) bt Marin Cilic (CRO x11) 6-7 (3/7), 6-4, 4-6, 7-6 (7/2), 6-3
Nicolas Mahut (FRA) bt Philipp Kohlschreiber (GER) 6-3, 6-3, 6-3
Casper Ruud (NOR) bt Matteo Berrettini (ITA x29) 6-4, 7-5, 6-3
Roger Federer (SUI x3) bt Oscar Otte (GER) 6-4, 6-3, 6-4
Kei Nishikori (JPN x7) bt Jo-Wilfried Tsonga (FRA) 4-6, 6-4, 6-4, 6-4
Laslo Djere (SRB x31) bt Alexei Popyrin (AUS) 6-4, 7-6 (7/4), 6-4
Pablo Carreno Busta (ESP) bt Alex De Minaur (AUS x21) 6-3, 6-1, 6-1
Benoit Paire (FRA) bt Pierre-Hugues Herbert (FRA) 6-2, 6-2, 5-7, 6-7 (6/8), 11-9
Juan Ignacio Londero (ARG) bt Richard Gasquet (FRA) 6-2, 3-6, 6-3, 6-4
Corentin Moutet (FRA) bt Guido Pella (ARG x19) 6-3, 6-1, 2-6, 7-5
David Goffin (BEL x27) bt Miomir Kecmanovic (SRB) 6-2, 6-4, 6-3
Rafael Nadal (ESP x2) bt Yannick Maden (GER) 6-1, 6-2, 6-4
Women
2nd round
Sloane Stephens (USA x7) bt Sara Sorribes Tormo (ESP) 6-1, 7-6 (7/3)
Polona Hercog (SLO) bt Jennifer Brady (USA) 6-3, 6-7 (8/10), 6-4
Garbine Muguruza (ESP x19) bt Johanna Larsson (SWE) 6-4, 6-1
Elina Svitolina (UKR x9) bt Kateryna Kozlova (UKR) -- walkover
Donna Vekic (CRO x23) bt Rebecca Peterson (SWE) 1-6, 6-1, 6-2
Johanna Konta (GBR x26) bt Lauren Davis (USA) 6-3, 1-6, 6-3
Viktoria Kuzmova (SVK) bt Kiki Bertens (NED x4) 3-1 -- retired
Marketa Vondrousova (CZE) bt Anastasia Potapova (RUS) 6-4, 6-0
Carla Suarez Navarro (ESP x28) bt Shelby Rogers (USA) 6-1, 6-7 (4/7), 6-3
Elise Mertens (BEL x20) bt Diane Parry (FRA) 6-1, 6-3
Anastasija Sevastova (LAT x12) bt Mandy Minella (LUX) 6-2, 6-4
Veronika Kudermetova (RUS) bt Zarina Diyas (KAZ) 7-5, 6-1
Kaia Kanepi (EST) bt Shuai Zhang (CHN) 6-7 (4/7), 6-0, 7-5
Petra Martic (CRO x31) bt Kristina Mladenovic (FRA) 6-2, 6-1
Karolina Pliskova (CZE x2) bt Kristina Kucova (SVK) 6-2, 6-2
