Melbourne - Seventh seed Dominic Thiem limped out of the Australian Open in the second round on Thursday when he retired when 7-5, 6-4, 2-0 down to young wildcard Alexei Popyrin.
The Austrian got through a first round five-setter against Benoit Paire that finished in the early hours of Wednesday morning and he never looked 100 percent against the Australian.
Thiem smashed his racquet at one point and called for the trainer before retiring to hand Popyrin, 19, the biggest win of his fledgling career.
"It's never easy winning like this, Dom played a tough first round. It's never easy winning like this," said the teenager.
But he added: "I always thought I was in the match, to be honest."
Popyrin will meet either 28th seed Lucas Pouille or Maximillian Marterer in the third round.
Results from Day 4 of the Australian Open on Thursday:
Men
Round 2
Kei Nishikori (JPN x8) bt Ivo Karlovic (CRO) 6-3, 7-6 (8/6), 5-7, 5-7, 7-6 (10/7)
Borna Coric (CRO x11) bt Marton Fucsovics (HUN) 6-4, 6-3, 6-4
Pablo Carreno-Busta (ESP x23) bt Ilya Ivashka (BLR) 6-2, 6-3, 7-6 (9/7)
Fabio Fognini (ITA x12) bt Leonardo Mayer (ARG) 7-6 (7/3), 6-3, 7-6 (7/5)
Joao Sousa (POR) bt Philipp Kohlschreiber (GER x32) 7-5, 4-6, 7-6 (7/4), 5-7, 6-4
Pierre-Hugues Herbert (FRA) bt Chung Hyeon (KOR x24) 6-2, 1-6, 6-2, 6-4
Milos Raonic (CAN x16) bt Stan Wawrinka (SUI) 6-7 (4/7), 7-6 (8/6), 7-6 (13/11), 7-6 (7/5)
Denis Shapovalov (CAN x25) bt Taro Daniel (JPN) 6-3, 7-6 (7/2), 6-3
David Goffin (BEL x21) bt Marius Copil (ROU) 5-7, 7-5, 6-2, 6-4
Daniil Medvedev (RUS x15) bt Ryan Harrison (USA) 6-3, 6-3, 6-3
Filip Krajinovic (SRB) bt Evgeny Donskoy (RUS) 6-4, 7-6 (10/8), 7-6 (7/2)
Alexei Popyrin (AUS) bt Dominic Thiem (AUT x7) 7-5, 6-4, 2-0 retired
Women
Round 2
Camila Giorgi (ITA x27) bt Iga Swiatek (POL) 6-2, 6-0
Wang Qiang (CHN x21) bt Aleksandra Krunic (SRB) 6-2, 6-3
Elina Svitolina (UKR x6) bt Viktoria Kuzmova (SVK) 6-4, 6-1
Karolina Pliskova (CZE x7) bt Madison Brengle (USA) 4-6, 6-1, 6-0
Anastasija Sevastova (LAT x13) bt Bianca Andreescu (CAN) 6-3, 3-6, 6-2
Elise Mertens (BEL x12) bt Margarita Gasparyan (RUS) 6-1, 7-5
Hsieh Su-wei (TPE x28) bt Laura Siegemund (GER) 6-3, 6-4
Madison Keys (USA x17) bt Anastasia Potapova (RUS) 6-3, 6-4
Timea Bacsinszky (SUI) bt Natalia Vikhlyantseva (RUS) 6-2, 7-5
Naomi Osaka (JPN x4) bt Tamara Zidansek (SLO) 6-2, 6-4
Zhang Shuai (CHN) bt Kristyna Pliskova (CZE) 6-3, 7-5
Simona Halep (ROU x1) bt Sofia Kenin (USA) 6-3, 6-7 (5/7), 6-4
Venus Williams (USA) bt Alize Cornet (FRA) 6-3, 4-6, 6-0