Shanghai - Australian Open champion Stan Wawrinka crashed out of his second successive tournament at the first hurdle Wednesday, losing his Shanghai Masters opener after squandering a 3-0 lead in the final set.
It was a misery for the fourth seed in Shanghai, who was in need of a morale-boosting victory after his last outing resulted in a first round exit at the Japan Open to 103-ranked Tatsuma Ito.
The world number four started brightly in Shanghai, taking the first set in his tightly-fought battle with Gilles Simon of France.
But his 29th ranked opponent fought back aggressively to stay in the match and force a decider.
The Swiss 29-year-old broke serve at his first attempt in the final set with a ferocious smash shot.
He then appeared to be cruising, pounding his chest with his fist as he entered the third game, which he won after saving two break points.
Simon, a former world number six, broke back at his next attempt and then forced his way to 3-3 in a marathon 10-minute game.
Wawrinka appeared to cave in three games later, meekly surrendering his serve without scoring a point before Simon marched to a 5-7, 7-5, 6-4 victory.
The result could undermine Wawrinka's bid to confirm his place at the end of season ATP World Tour Finals, which involves the world's top eight players.
He is in fourth position in the Race to London but is desperately chasing points as he vies to hold off a closing pack who are all competing in Shanghai.
Only five berths remain for the London tournament, as Novak Djokovic, Rafael Nadal and Roger Federer have already qualified.
The fifth seed in Shanghai, David Ferrer, also faced a tough battle in his opening match, but finally overcame Slovak Martin Klizan 4-6, 7-6 (7/4), 6-4.
Klizan dumped Rafael Nadal out of the China Open at the quarter final stage last week, but could not repeat his heroics against his Spanish opponent at the Masters 1000 event.
Meanwhile, 10th seed Grigor Dimitrov of Bulgaria crashed out to Julien Benneteau of France 7-5, 6-3.
Shanghai Masters results on Wednesday:
Novak Djokovic (SRB x1) bt Dominic Thiem (AUT) 6-3, 6-4
Andy Murray (GBR x11) bt Jerzy Janowicz (POL) 7-5, 6-2
David Ferrer (ESP x5) bt Martin Klizan (SVK) 4-6, 7-6 (7/4), 6-4
Roberto Bautista (ESP x14) bt Vasek Pospisil (CAN) 7-6 (7/1), 3-6, 6-4
Julien Benneteau (FRA) bt Grigor Dimitrov (BUL x10) 7-5, 6-3
Jack Sock (USA) bt Kei Nishikori (JPN x7) 7-6 (7/5), 6-4
Tomas Berdych (CZE x6) bt Richard Gasquet (FRA) 6-3, 6-1
Malek Jaziri (TUN) bt Wang Chuhan (CHN) 6-0, 6-4
Gilles Simon (FRA) bt Stanislas Wawrinka (SUI x4) 5-7, 7-5, 6-4
Juan Monaco (ARG) bt Milos Raonic (CAN x8) 5-2 (Monaco won after retirement from Raonic)
Mikhail Youzhny (RUS) bt Ivan Dodig (CRO) 7-6 (9/7), 6-7 (4/7), 6-3
John Isner (USA x13) bt Steve Johnson (USA) 7-6 (8/6), 7-6 (9/7)
Feliciano Lopez (ESP) bt Rafael Nadal (ESP x2) 6-3, 7-6 (8/6)