Cape Town - Mamelodi Sundowns face a massive challenge in the next step of their CAF Champions League campaign when they meet Egyptian giants Al Ahly in Saturday's first leg quarter-final clash at Lucas Masterpieces Moripe Stadium.
The Brazilians come into the contest in solid having won two, lost two and drawn one in all competitions.
Going into the encounter Mosimane revealed that Anthony Laffor could be out for the season with a knee injury which requires surgery.
Meanwhile, Jeremy Brockie is not available due to a groin problem he is battling with.
Ricardo Nascimento and Aubrey Ngoma are also both doubtful as they are battling with tonsillitis.
With that said, good news for Sundowns is that forward Phakamani Mahlambi has returned to training following injury.
As such, Mosimane is under no illusions of the tough task facing his team.
He told reporters: "They are the biggest team on the continent. Just look at the badge, just look at the stars. Then you realise that we are small boys, we have not done nothing.
"But it's okay, we need to try more on the continent and raise the flag."
The visitors are in good form in the Egyptian Premier League though they trail leaders Zamalek by two points.
In recent matches coach Martin Lasarte has rotated his squad in order to keep his players fresh and fighting fit.
He said: "I was obliged to make many changes in the squad. Finally, I must get the most benefit of the big squad that we have.
"We faced Zamalek few days ago and now we are preparing for facing Sundowns in a difficult match in the Champions League, so rotation was a must..."
Kick-off is at 15:00.