Cape Town - Mamelodi Sundowns will go into the second leg of the MTN8 semi-final against Supersport United on Wednesday as favourites after a 1-1 draw in the first encounter.
Masandawana will be the designated home team at the Lucas Moripe Stadium even they though both clubs share the venue.
Thamsanqa Gabuza gave Matsatsantsa the lead in the first game but Gaston Sirino got the all-important away goal for the Brazilians.
Sundowns head coach Pitso Mosimane has urged his team to score more goals in domestic battles and there would no better time to start than in this crucial derby.
Gabuza and Bradley Grobler have formed a potent front two for Supersport with the Sundowns defence having to be at the best to keep the forwards at bay.
Sirino, Themba Zwane and Lebogang Maboe will again be key for Masandawana as Supersport have to stop their key interchanges between the lines.
The result could hinge on who wins the battle in the middle of the park as midfielders Hlompho Kekana and Dean Furman need to put in big performances for their respective teams.
Both Tshwane sides have made decent starts to their league campaigns with Sundowns having collected eight points from four games and their neighbours having the same amount of points but having played a game more.
Kick-off is at 19:30.
- TeamTalk Media