Cape Town - SuperSport United will look to put a dent in the Absa Premiership title ambitions of their local rivals Mamelodi Sundowns.
SuperSport returned to winning form in the league by beating Jomo Cosmos 4-2 away on February 27.
The Tshwane side has claimed 12 points from 10 home matches this season.
Matsatsantsa are placed 10th on the Absa Premiership log with 27 points from 21 matches.
Sundowns extended their unbeaten run in the league to 17 matches with a 2-1 win over Black Aces on February 24.
The Tshwane side has claimed 20 points from 10 away matches this season.
The Brazilians are placed first on the Absa Premiership log with 49 points from 21 matches.
In head-to-head stats, Sundowns and SuperSport have met in 49 league matches since 1990.
The Brazilians have claimed 24 wins compared to 14 for Matsatsantsa, while 11 matches have been drawn.
SuperSport have won five of their 24 home matches against Sundowns, suffering 13 defeats in the process.
When the teams met earlier this season, the Brazilians claimed a 2-0 home win.
Kick-off is scheduled for 19:30 at the Lucas Moripe Stadium on Tuesday, March 1.