Cape Town Mamelodi Sundowns will play Ghanaian club Medeama SC in the play-off round of the CAF Confederation Cup next month.
Medeama have only been in existence since 2002, and have never won the domestic league in Ghana.
Sundowns were knocked out of the CAF Champions League on Wednesday night after losing on the away goals rule to DR Congo outfit AS Vita.
The Brazilians, together with the seven other losing teams from the Champions League second round, subsequently went into the draw with the eight that qualified from the first two rounds of the Confederation Cup.
Pitso Mosimane's side will play the first match of the two-legged knockout tie at home, the match scheduled for 6-8 May. The return game will be played between 17-18 May.
Full 2016 CAF Confederation Cup play-off draw:
Stade Malien vs FUS Rabat
Al Ahli Tripoli vs Misr Makkassa
Mamelodi Sundowns vs Medeama SC
Al Merreikh vs Kawkab Marrakesh
Young Africans vs GD Esperanca
Gabseien vs TP Mazembe
CF Mounana vs Etoile du Sahel
MO Bejaia vs Esperance