Cape Town - Jomo Cosmos and Chippa United will battle for three Absa Premiership points when they meet at Olen Park.
Cosmos suffered a fifth defeat in their last seven league matches when they were beaten 3-1 at Bidvest Wits on November 8.
The Potchefstroom-based side has claimed five points from as many home matches this season.
Ezenkosi are placed 14th on the Absa Premiership log with seven points from 10 matches.
Chippa suffered a second defeat from their last three league matches when they were beaten 1-0 at home by Mamelodi Sundowns on November 4.
The Eastern Cape side has claimed three points from four away matches this season.
The Chilli Boys are placed eighth on the Absa Premiership log with 13 points from 10 matches.
In head-to-head stats, this will be the first top flight league meeting between Cosmos and Chippa.
Kick-off is at 15:30 on Sunday, 22 November.