Cape Town - Mamelodi Sundowns will be determined to avoid a late slip-up in the Premiership, but face a SuperSport United side scrapping it out for the top eight.
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The Brazilians have already surrendered the top-flight crown to Kaizer Chiefs, who rubbed further salt in their wounds after a smash-and-grab 1-0 win in Tshwane last week.
However, Pitso Mosimane's men still have second place and CAF Champions League football to play for, and with Orlando Pirates only two points adrift, a positive result this week will be vital.
The Pretoria giants will also be eager to build up a head of steam in their final two league matches, the second of which comes on Saturday against University of Pretoria, as they gear up for this month's Nedbank Cup final against Ajax Cape Town.
SuperSport, though, will be determined to cement their place in the top eight, with United - beaten Ke Yona semi-finalist against Ajax - currently seventh in the standings, four points clear of ninth with two matches to go.
On the team front, Matsatsantsa will have to do without the services of Tamsanqa Teyise, who is missing through suspension, while Siyanda Zwane will play no further part in Sundowns' league campaign after picking up a red card in the loss to Chiefs.
Kick-off is at 19:30 on Wednesday, May 6.