Cape Town - SuperSport United will look to bounce back from Absa Premiership defeat when they host Ajax Cape Town at Peter Mokaba Stadium.
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SuperSport suffered their first league defeat of 2015 when they were beaten 5-2 at home by AmaZulu last weekend.
The Tshwane side has claimed 14 points from 11 home matches this season.
Their next three league opponents are Bloemfontein Celtic (away), University of Pretoria (home) and Maritzburg United (home).
Matsatsantsa are placed eighth on the Absa Premiership log with 27 points from 20 matches.
Ajax suffered their sixth away defeat of the season when they lost 1-0 at Kaizer Chiefs in midweek.
The Cape Town side has claimed six points from 10 away matches this season.
Their next three league opponents are Black Aces (home), Platinum Stars and Free State Stars (both away).
The Urban Warriors are placed sixth on the log with 28 points from 21 matches.
In head-to-head stats, SuperSport and Ajax have met in 31 league matches since 1999/2000.
Matsatsantsa have 12 wins compared to 10 for the Urban Warriors, while nine matches have been drawn.
SuperSport have won eight of their 15 home matches against Ajax, suffering four defeats in the process.
When the teams met earlier this season in Cape Town they played out a goalless stalemate.
Kick-off is at 18:00 on Saturday, March 7.