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"There is a good balance to the side," De Sa said.
"That's made a difference, with the youth and the experience, and we need to keep that up."
Wits, fresh off a 3-1 win over Orlando Pirates in the league campaign, have risen to seventh in the table, and they will hope to continue their fine run of form.
"We've always been up and down -- this season even more so," De Sa said.
"One good performance and one good win, and then a terrible performance after that.
"So I think just to have three victories in a row -- two in the league and one in the cup -- we're in good form at the moment and the side is doing well."
De Sa believed playing at home would give the Students a distinct advantage.
"We're one of the few teams that own a stadium, so we've got to make use of it, and make it into our fortress," he said.
"We need to make sure we start winning some matches there.
"We have [won at home] in the past, but this season it hasn't been that good for us.
"We've had some dismal performances there and we have to turn that around."
Past matches this season would not be a factor at the weekend, De Sa believed, with Wits having defeated Santos in a league clash in August.
"You can't think too much about previous games," he said.
"If you look at it like that, they also beat us in the Telkom Knockout last year, and you know every game is new.
"They've changed players -- so have we -- and new personnel, so it's a new season and you can't look too much into the past.
"We did beat them in the first league game, but it was a close affair, and it wasn't one-sided or anything like that.
"We had a chance but they had some very good chances too.
"If anything, we are going to learn from that, and study that pretty well and hopefully learn from that performance."
In the other semi-final, on Saturday, Pirates travel to Durban to face Golden Arrows as the Buccaneers go in search of the only title that eluded them last season.
