Cape Town - Manchester United have been handed an FA Cup quarter-final trip to Wolves, while Manchester City were given an away date with Swansea in Monday's draw.
United's reward for knocking out holders Chelsea with an impressive 2-0 win at Stamford Bridge on Monday was another away fixture against Premier League opposition.
Bidding to win the FA Cup a record-equalling 13th time and first since 2016, United will head to Molineux to face a Wolves side who won at Bristol City on Sunday.
"An away tie again after Arsenal and Chelsea but that's it. We'll have to do it the hard way, Wolves are a tough team to play against," United interim manager Ole Gunnar Solskjaer said.
Pep Guardiola's Manchester City will return to south Wales for their clash with Championship team Swansea after beating Newport in the fifth round.
Top-flight strugglers Brighton travel to 2004 FA Cup finalists Millwall, who shocked Premier League side Everton in the fourth round.
There is an all-Premier League tie at Vicarage Road where Watford host Crystal Palace in a repeat of the 2016 FA Cup semi-final won by the Eagles.
Ties to be played March 15-17
Draw for the FA Cup quarter-finals made on Monday:
Swansea v Manchester City
Watford v Crystal Palace
Wolves v Manchester United
Millwall v Brighton