Madrid - Gary Neville has a great chance to seal his first win as Valencia boss at the third attempt when Los Che host third tier Barakaldo at the Mestalla.
Valencia already lead the Basques 3-1 from the first leg before Neville's appointment a fortnight ago.
Real Madrid's expulsion from the competition for fielding an ineligible player against Cadiz could open the door for a winner outside Spanish football's dominant top three of Real, Barcelona and Atletico Madrid for the first time since 2010.
And Neville has targeted winning one of the Cup or the Europa League as one of his prime targets in his short stint at Valencia between now and the end of the season.
"Valencia have to win trophies," he told the club's website.
"The players have to experience the medal round their neck to give them confidence and belief."