Clairefontaine-en-Yvelines - Manchester United pair Anthony Martial and Paul Pogba will miss France's key Nations League fixture against the Netherlands and a Uruguay friendly through injury, the French Football Federation (FFF) announced on Monday.
Both players arrived in Paris for assessment but were deemed unfit to feature for Didier Deschamps' side who would qualify for the Nations League finals by beating the Dutch.
Forward Martial who is in fine form for his club scoring six goals in his last five Premier League, is suffering from a groin injury.
World champion midfielder Pogba who missed the Red Devils' derby defeat to Manchester City on Sunday through injury has a thigh problem.
Arsenal striker Alexandre Lacazette and Tottenham's Moussa Sissoko replace the United duo in Deschamps' squad.
Lacazette's last cap came in November 2017's draw to Germany and Sissoko has not featured in an international game since the victory over Belarus last October.
The 2018 World Cup winners travel to Rotterdam to face Ronald Koeman's Netherlands on Friday before a friendly against Uruguay the following Tuesday in Paris.