Lille - French police fired tear gas and charged England supporters during trouble in central Lille on Wednesday which left at least one injured, AFP reporters said.
Fans were also involved in a brawl on a train heading for Lille where England supporters have gathered ahead of their key match against Wales on Thursday.
Fighting broke out near the main station in Lille, north east France, while a car was seriously damaged.
Riot squad members fired tear gas and then charged a group of British fans in the city ahead of England's next match in nearby Lens on Thursday.
An AFP reporter saw one fan being treated on the ground. Paramedics appeared to be performing a cardiac massage though the nationality of the injured fan was unclear.
Hundreds of supporters remained in the streets after the incident, drinking beer as anti-riot police looked on.
A separate brawl broke out between England and Wales fans on a train travelling from Calais to Lille. About 15 men were involved, a French security official told AFP.
"There was a fight between England and Wales fans. It was quite violent," the source, who spoke on condition of anonymity, told AFP.
Several arrests were made when the train arrived in Lille on Wednesday evening with a British undercover police officer who was onboard helping French authorities to identify the aggressors, the official said.