Harrison - Roma withstood a dramatic, late Tottenham comeback to send the Premier League team to their first defeat of this pre-season in a bad tempered affair which ended 3-2 in remarkable fashion.
Tackles were flying in all over the pitch and Spurs manager Mauricio Pochettino was livid with match officials in the second half, although much of his anger would have been directed at his players who badly under-performed at Red Bull Arena.
Diego Perotti put the Italian team ahead with a penalty on 12 minutes.
On 69 minutes, Eusebio Di Francesco's side doubled their lead as sub Kevin Vimmer's cross fell to Turkish midfielder Cengiz Under, whose goal appeared to have sealed the win.
But Harry Winks reduced the arrears on 86 minutes when he prodded home from four yards, and when Vincent Janssen scored in stoppage time, the Premier League team looked to have gained a draw that would have sent the International Champions Cup friendly to a penalty shoot-out.
Moments later, however, Marco Tumminello scored in dramatic fashion to sink the Londoners once and for all.
On the day that Daniel Levy, the Tottenham owner, stressed his lack of transfer activity this summer is irrelevant because of the club's thriving youth academy, manager Mauricio Pochettino fielded a number of younger players.
Central defender Cameron Carter-Vickers, left back Kyle Walker-Peters and midfielder Josh Onomah all started for a Spurs team who arrived in New York with a spring in their step following Saturday night's 4-2 win over Paris Saint-Germain in Orlando.
Roma, who lost their previous game to the French champions on penalties, fielded a near full strength side with former Manchester City player Edin Dzeko and Aleksandar Kolarov both renewing acquaintances with the Premier League club.
And the Italians controversially took the lead on 12 minutes through Perotti's penalty.
Carter-Vickers was adjudged to have handled a Radja Nainggolan cross and although referee Hilario Grajeda was initially unsure, his assistant indicated the Spurs player did indeed handball in the area allowing Perotti to step up and steer past Michel Vorm.
The English side, cheered on by a strong contingent of supporters, failed to get into their stride and it wasn't until the 24th minute that a chance finally fell their way.
Kane left furious
Harry Kane was inches away from a cross before Mousa Dembele hit the bar from close range.
Kane, the England striker, had been very quiet but he sprung into life on 36 minutes, powerfully holding off his marker before unleashing a shot from 20 yards which was well saved by Roma's keeper Alisson.
Pochettino removed the three young hopefuls at half-time with only Walker-Peters impressing, yet three minutes after the re-start Kane was left furious after Fazio brought him down in the area only for the referee to dismiss his penalty claims.
The striker's anger spilled over soon after when he smashed into Kostas Manolas, leaving the Roma defender sprawled out on the turf.
Manager Pochettino then became embroiled in a lengthy argument with the fourth official, who appeared to try and send the Argentine off before relenting and allowing him to continue sitting on the sidelines.
"It was a situation that we were talking in Spanish, not in English," Pochettino said. "But I believe it was a chat that okay, we were talking and started to speak louder.
But for me then I said to him, 'I apologise'. Maybe a bit nervous for some situation on the pitch. But he wanted send me off, but I said 'come on we were talking in Spanish and nobody could understand us'.
"It was all good I think. I said sorry and he was fine."
Roma now travel to Boston for their final International Champions Cup match with Serie A rivals Juventus while Tottenham travel to Nashville to take on Pep Guardiola's Manchester City.