Cape Town - Apart from the conventional fierce regional rivalry, Manchester City v Manchester United on Sunday is also a scrap for Champions League status next season - but the hosts are widely expected by our forecasters to tighten the screws on that front.
Fourth-placed City lead the Red Devils (sixth) by four points and all but one of us see that advantage stretching to a formidable seven once the dust settles on the derby.
Each round of the 2015/16 Premiership campaign, a group of our staff has a crack at predicting the results - do the exercise yourself, if you like, and see how you compare afterwards.
Compiled by Rob Houwing (Newcastle-partial), the others are Garrin Lambley (Everton), Herman Mostert (Chelsea), and a trio of Manchester United devotees in Tashreeq Vardien, Lloyd Burnard and Maano Nekhavhambe.
Three points are awarded for an entirely correct scoreline, and one for right result.
OUR FORECASTS:
EVERTON v ARSENAL
Saturday, 14:45
Rob: 1-2
Garrin: 1-1
Herman: 1-1
Tashreeq: 2-1
Lloyd: 1-1
Maano: 1-0
Last season: 2-2
CHELSEA v WEST HAM
Saturday,17:00
Rob: 2-0
Garrin: 2-1
Herman: 2-1
Tashreeq: 1-1
Lloyd: 2-1
Maano: 1-1
Last season: 2-0
CRYSTAL PALACE v LEICESTER
Saturday, 17:00
Rob: 1-2
Garrin: 1-1
Herman: 1-2
Tashreeq: 0-1
Lloyd: 0-1
Maano: 0-1
Last season: 2-0
WATFORD v STOKE
Saturday, 17:00
Rob: 1-1
Garrin: 2-1
Herman: 1-1
Tashreeq: 1-0
Lloyd: 1-0
Maano: 1-0
Last season: Not applicable
WEST BROM v NORWICH
Saturday, 17:00
Rob: 2-1
Garrin: 2-0
Herman: 1-1
Tashreeq: 0-0
Lloyd: 1-1
Maano: 2-1
Last season: Not applicable
SWANSEA v ASTON VILLA
Saturday, 19:30
Rob: 2-0
Garrin: 2-1
Herman: 2-1
Tashreeq: 2-0
Lloyd: 2-0
Maano: 2-0
Last season: 1-0
NEWCASTLE v SUNDERLAND
Sunday, 15:30
Rob: 1-1
Garrin: 1-1
Herman: 1-2
Tashreeq: 1-1
Lloyd: 2-1
Maano: 1-0
Last season: 0-1
SOUTHAMPTON v LIVERPOOL
Sunday, 15:30
Rob: 1-2
Garrin: 1-1
Herman: 1-1
Tashreeq: 1-0
Lloyd: 1-1
Maano: 0-1
Last season: 0-2
MANCHESTER CITY v MANCHESTER UNITED
Sunday, 18:00
Rob: 0-0
Garrin: 2-1
Herman: 2-1
Tashreeq: 1-0
Lloyd: 2-0
Maano: 1-0
Last season: 1-0
TOTTENHAM v BOURNEMOUTH
Sunday, 18:00
Rob: 1-0
Garrin: 2-1
Herman: 3-0
Tashreeq: 1-0
Lloyd: 3-0
Maano: 2-1
Last season: Not applicable
*LEADERBOARD:
208 - Maano (4 points in last round)
189 - Garrin (5)
183 - Tashreeq (5) & Rob (2)
181 - Lloyd (7)
176 - Herman (4)