London - Alvaro Morata scored twice as holders Chelsea began their FA Cup defence with a 2-0 win over Nottingham Forest in a match where a tearful Cesc Fabregas appeared to bid farewell to English football.
The third round is the stage where top-flight clubs enter the world's oldest senior knockout football tournament and has traditionally been associated with upsets.
But there was only one 'giant-killing' on Saturday with third-tier Gillingham beating Premier League Cardiff 1-0.
Bristol City, unbeaten in eight second division Championship games, defeated top flight basement club Huddersfield by the same score thanks to Josh Brownhill's 72nd-minute goal.
Crystal Palace left it late to see off fourth-tier Grimsby 1-0, with Jordan Ayew scoring four minutes from time.
Meanwhile, second division Derby, managed by former England midfielder Frank Lampard, came from 2-0 down to draw 2-2 with Premier League strugglers Southampton.
Newcastle were also held to a draw, a Matt Ritchie penalty five minutes from time ensuring a 1-1 result against Championship club Blackburn.
But Arsenal, the record 13-time FA Cup winners, won 3-0 at Blackpool.
Both Morata and Fabregas have been linked with moves away from Stamford Bridge in the January transfer window - the latter is reportedly set to join a Monaco side managed by former Arsenal team-mate Thierry Henry.
Fabregas, captain for the day, saw his poor 30th-minute penalty saved by Luke Steele.
But two goals in the space of 10 minutes early in the second half from the previously misfiring Morata, settled the tie.
Chelsea coach Carlo Cudicini, standing in on media duty instead of manager Mauricio Sarri, was uncertain when asked if Fabregas had played his last game for the Blues.
"I personally don't know," he said.
"He (Fabregas) has been fantastic for the teams he played for before us and the contribution he has given to this club and to this team has been amazing. Cesc is a top, top player."
Cardiff conceded eight minutes from time when midfielder Elliott List scored for south-east club Gillingham.
"I bet we would have missed their chance if we'd had it," said Cardiff manager Neil Warnock. "We wouldn't have scored in a million years."
It seemed Southampton were cruising into the fourth round following goals early in each half by Nathan Redmond but Derby hit back with two in quick succession after the hour mark through Jack Marriott and Tom Lawrence.
Everton survived a scare to see off fourth-tier Lincoln 2-1 at Goodison Park.
Ademola Lookman and Bernard put the Toffees 2-0 up by the 14th minute but the hosts, 58 places ahead of their opponents, struggled after Michael Bostwick pulled a goal back in the 28th minute.
Ole Gunnar Solskjaer enjoyed a fifth successive win since becoming interim manager of Manchester United following the dismissal of Jose Mourinho with a 2-0 win over Reading.
United, last season's losing finalists, scored twice before half-time, through Juan Mata and Romelu Lukaku.
"You can't ask for more than going through but the way we played wasn't the best," Solskjaer told the BBC.
Marko Arnautovic had a curious match as West Ham beat Championship club Birmingham 2-0.
The Austrian striker scored as early as the second minute but was substituted after 19 minutes by manager Manuel Pellegrini.
"He felt a pain in his back at the beginning," said Pellegrini. "He wanted to continue after that, but it was not good to take a risk."
Andy Carroll, the man who replaced Arnautovic, made it 2-0 in the 90th minute with his first goal since April.
Elsewhere, an all-Premier League clash saw Brighton win 3-1 away to south coast rivals Bournemouth.
Premier League strugglers Burnley needed a late penalty from Chris Wood to see off third-tier Barnsley 1-0.
Arsenal had a bizarre build-up to their tie when a Blackpool fan climbed onto the roof of the coach taking the squad to Bloomfield Road.
Eventually, after being spoken to by police officers, the man came down off the roof after some 40 minutes. Lancashire police then arrested the man.
Joel Willock, one of four teenagers in Arsenal's side, scored twice before half-time, with Alex Iwobi added a third goal late on.
League One leaders Portsmouth, the 2008 FA Cup winners, needed an Andre Green stoppage-time goal in a 1-0 victory away to Championship high-flyers Norwich, down to 10 men after Grant Haley's early red card.
Liverpool, the Premier League leaders, play Wolves at Anfield on Monday.
Tottenham Hotspur became the first club into the fourth round this season with a 7-0 rout of fourth-tier Tranmere on Friday.
Collated English FA Cup results on Saturday:
Accrington 1 (Key 76) Ipswich 0
Aston Villa 0 Swansea 3 (Baker-Richardson 2, Dyer 47, Fulton 78)
Blackpool 0 Arsenal 3 (Willock 11, 37, Iwobi 82)
Bournemouth 1 (Pugh 55) Brighton 3 (Knockaert 31, Bissouma 34, Andone 64)
Bolton 5 (Donaldson 58, Magennis 61, 80, 87, Guthrie 63) Walsall 2 (Cook 19, Beevers 68-og)
Brentford 1 (Maupay 80-pen) Oxford 0
Bristol City 1 Brownhill 72) Huddersfield 0
Burnley 1 (Wood 90-pen) Barnsley 0
Chelsea 2 (Morata 49, 59) Nottingham Forest 0
Crystal Palace 1 (Ayew 86) Grimsby 0
Derby 2 (Marriott 58, Lawrence 61) Southampton 2 (Redmond 4, 48)
Everton 2 (Lookman 12, Bernard 14) Lincoln 1 (Bostwick 28)
Fleetwood 2 (Madden 70, Evans ) AFC Wimbledon 3 (Barcham 16, Hartigan 55, Appiah 90)
Gillingham 1 (List 81) Cardiff 0
Manchester United 2 (Mata 22-pen, Lukaku 45+4) Reading 0
Middlesbrough 5 (Assombalonga 47, 70, Friend 50, Wing 62, Fletcher 87) Peterborough 0
Newcastle 1 (Ritchie 85-pen) Blackburn 1 (Dack 56)
Norwich 0 Portsmouth 1 (Green 90+4)
Sheffield Wednesday 0 Luton 0
Shrewsbury 1 (Norburn 45-pen) Stoke 1 (Crouch 78)
West Brom 1 (Sako 31) Wigan 0
West Ham 2 (Arnautovic 2, Carroll 90) Birmingham 0
Playing on Sunday (16:00 SA time unless stated)
Fulham v Oldham
Manchester City v Rotherham
Millwall v Hull
Newport v Leicester (18:30)
Preston v Doncaster
QPR v Leeds
Sheffield Utd v Barnet
Woking v Watford (17:00)
Playing on Monday
Wolves v Liverpool (21:45)
Played on Friday
Tranmere 0 Tottenham 7 (Aurier 40, 55, Llorente 48, 71, 72, Son 57, Kane 82)