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The central defender has recovered from an Achilles injury that has kept him out since August.
"It's great to have Michael coming back, he's been out quite a while now," manager Harry Redknapp said on the Premier League club's website (www.tottenham hotspur.com).
"He's worked hard to get back to fitness and is looking forward to playing."
Winger Aaron Lennon will also return after injuring his hamstring against Sunderland on December 18, and will feature in a much-changed Tottenham side.
"We will change it around," added Redknapp, whose club are third in the league with a game in hand.
"That's no disrespect to Cheltenham, but we've played the same players (over Christmas and New Year) and we can't keep playing them. We need to use the squad."
