Nyon - European champions Chelsea will play Basel in the Europa League semi-finals, with the first-leg match in Switzerland.
Fenerbahce face Benfica with the opening leg played in Turkey.
Basel and Fenerbahce have reached their first semi-final in any European club competition.
All four teams began the season in the Champions League before being eliminated and dropping into the second-tier competition.
First-leg matches will be played on April 25. Return games are on May 2.
The final is on May 15 at Amsterdam Arena.
The fixtures for the Europa League semi-finals following the draw made at UEFA headquarters in Nyon, Switzerland, on Friday:
Semi-finals first leg - Thursday, April 25
Fenerbahce (TUR) v Benfica (POR)
Basel (SUI) v Chelsea (ENG)
Semi-finals second leg - Thursday, May 2
Benfica (POR) v Fenerbahce (TUR)
Chelsea (ENG) v Basel (SUI)