Cape Town - Manchester City will attempt to recover from a 1-0 first-leg defeat when they host Premier League rivals Spurs in the Champions League.
Spurs secured a narrow lead in the first game when Son Heung-min scored the only goal at their brand-new state-of-the-art stadium, so City have plenty to do to progress into the semi-finals.
However, Pep Guardiola's star-studded squad, who are still chasing the quadruple, will be expected to recover in what should be another tight all-English showdown.
This is the second of three games between the two sides as they also meet at the Etihad in a huge league game on Saturday, but the focus for now is on Europe as both teams look to make it into the semis.
Despite all their riches, City have only made the Champions League last four once, back in 2016, while Tottenham have never progressed past the quarter-finals.
Mauricio Pochettino knows seeing off City will be a huge challenge but, if they manage to pull it off, it will be hailed as a major achievement, with Juventus or Ajax waiting.
Guardiola has declared key midfielder Fernandinho and main goal threat Sergio Aguero both fit for the second leg, with only Oleksandr Zinchenko absent through injury.
Spurs are without Harry Kane, who picked up a season-ending ankle injury in the first game, while Dele Alli is a doubt with a wrist injury.
Fernando Llorente, who was in line to be given another chance up front in Kane's absence, will be given a late fitness test on a minor knock, but Eric Dier, Serge Aurier and Erik Lamela are all still out injured.
Kick-off is at 21:00 (SA time).