London - Manchester City will have to face the threat of Barcelona without talisman Yaya Toure, who still out suspended.
The hosts will be without Yaya Toure as he completes a three-game ban, but City's group-stage great escape - a stirring 3-2 win against Bayern Munich, in which Sergio Aguero scored a hat-trick, and a 2-0 victory at Roma - was orchestrated without the giant Ivorian in their ranks.
With James Milner expected to return from a knee injury and January signing Wilfried Bony in line for his Champions League debut, City are otherwise at full strength, but Aguero, Zabaleta, Gael Clichy and Edin Dzeko are all one booking away from suspension.
Barcelona's group-phase progress was rather more serene, despite a 3-2 loss at Paris Saint-Germain, and their only absentees are long-term injury victims Thomas Vermaelen and Douglas.
Manchester City host Barcelona at the Etihad Stadium.
The match kicks off at 21:45.