Frankfurt - Group E of the Champions League features two teams that need to recover from defeats in opening matches.
Manchester City's last victory against an Italian team, home or away, dates back to the 1978-79 UEFA Cup, when it beat AC Milan 3-1.
But it is also unbeaten at home in four matches against Italian opposition.
City had a 50-50 record at home last season in the Champions League — two victories and two losses.
Roma travels to Manchester City hoping its perfect record will remain intact at the end of a crucial week for the Italian club.
Rudi Garcia's team is 6-0 in all competitions and has a 14-2 goal difference.
After the trip to Manchester, Roma faces what is already being billed as a title showdown with Juventus on Sunday.
"It will be a really fantastic match in Manchester," Garcia said.
"They have zero points, they have the pressure. They have to get a result. Then we will have plenty of time to get our strength back for the next league match.
"We are a solid team and this group has confidence in their own abilities. That's what I like the most. Maybe we'll suffer a bit at Manchester, but we will do everything we can to score and get a positive result. I believe this group is ready to deal with difficult moments. They will happen during this season, but after 15 points and a good start in the Champions League we shouldn't be thinking of difficult moments."
Roma will be boosted by the return of Juan Manuel Iturbe, who has been sidelined with injury since the 5-1 victory over CSKA Moscow, which saw him score once and set up two other goals in 25 minutes.
But Roma has won only once in 14 trips to England and lost all three matches in Manchester - to United.