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Nice - Fijian-born winger Alivereti Raka and backrower Francois Cros will make their debuts for France on Saturday in a World Cup warm-up match against Scotland.
Veteran Camille Lopez, 30, wins back his place at fly-half, preferred as starter to Romain Ntmack, who will sit on the bench for the match in Nice.
Ahead of the September 20-November 2 World Cup in Japan, French coach Jacques Brunel has been keeping a watchful eye on Clermont's gifted Raka, 24, who obtained French citizenship only last December.
"Everybody knows his qualities and his effectiveness," said Brunel.
"He has shown them for a while now... We are expecting him to be as effective for the France team as he is for his club,."
Gros, for his part, made a strong case for inclusion at flanker during a stunning past season performance with French champions Toulouse. He gets his chance with regular back rowers Wenceslas Lauret and Yacouba Camara unavailable through injury.
Toulon's Charles Ollivon also returns at flanker after two years to win his seventh cap after struggling with a shoulder injury.
Lopez, dropped after he criticised the coaching setup in February following the sides 44-8 defeat by England, is back in favour and will link up with Toulouse scrum-half Antoine Dupont.
Cros and Ollivon join Gregory Alldritt (five caps) at number eight who is preferred to Louis Picamoles in an experimental backrow combination playing together for the first time.
Paul Gabrillagues gets his first start in the second row since June last year while in the front row Camille Chat starts at hooker in place of Guilhem Guirado, the team captain who is injured along with prop Demba Bamba.
France play Scotland again in Edinburgh on August 24 and complete their three-match World Cup preparations against Italy on August 30 at the Stade de France.
Meanwhile coach Brunel announced that centre Geoffrey Doumayrou, not named in the side to play Scotland, will miss out on the World Cup because of an Achilles tendon injury after being named in the original squad to go to Japan.
Teams:
France
15 Maxime Medard, 14 Damian Penaud, 13 Gael Fickou, 12 Wesley Fofana, 11 Alivereti Raka, 10 Camille Lopez, 9 Antoine Dupont, 8 Charles Ollivon, 7 Gregory Alldritt, 6 Francois Cros, 5 Sebastian Vahaamahina, 4 Paul Gabrillagues, 3 Rabah Slimani, 2 Camille Chat, 1 Jefferson Poirot (captain)
Substitutes: 16 Peato Mauvaka, 17 Dany Priso, 18 Emerick Setiano, 19 Felix Lambey, 20 Louis Picamoles, 21 Baptiste Serin, 22 Romain Ntamack, 23 Thomas Ramos
Scotland
15 Stuart Hogg, 14 Darcy Graham, 13 Huw Jones, 12 Duncan Taylor, 11 Byron McGuigan, 10 Adam Hastings, 9 Ali Price, 8 Josh Strauss, 7 Jamie Ritchie, 6 John Barclay, 5 Grant Gilchrist, 4 Ben Toolis, 3 Simon Berghan, 2 Stuart McInally (captain), 1 Jamie Bhatti
Substitutes: 16 George Turner, 17 Gordon Reid, 18 Zander Fagerson, 19 Scott Cummings, 20 Matt Fagerson, 21 George Horne, 22 Rory Hutchinson, 23 Blair Kinghorn
