Cape Town - France have made 11 changes to the side which last turned out in the Six Nations for the first Test against South Africa at Loftus Versfeld on Saturday.
Kick-off is at 17:00.
Only Brice Dulin, Gaël Fickou, Virimi Vakatawa and Louis Picamoles remain from that win over Wales, with Yoann Huget coming into the back three.
Henry Chavancy of Racing 92 makes a first Test start for France at outside centre, with Maxime Machenaud and Jules Plisson forming the halfback pairing.
Picamoles is joined in the back row by Loann Goujon and Yacouba Camara, while the new lock combination partners Yoann Maestri, the France captain, and Julien le Devedec together.
And an entirely new front row sees props Uini Atonio and Jefferson Poirot both start, with Clément Maynadier at hooker in place of regular France captain Guilhem Guirado.
Possible new caps off the bench include the La Rochelle duo Mohamed Boughanmi and Vincent Rattez.
15 Andries Coetzee, 14 Raymond
Rhule, 13 Jesse Kriel, 12 Jan Serfontein, 11 Courtnall Skosan, 10 Elton
Jantjies, 9 Ross Cronje, 8 Warren Whiteley (captain), 7 Oupa Mohoje, 6
Siya Kolisi, 5 Franco Mostert, 4 Eben Etzebeth, 3 Frans Malherbe, 2
Malcolm Marx, 1 Tendai Mtawarira
Substitutes: 16 Bongi Mbonambi,
17 Steven Kitshoff, 18 Coenie Oosthuizen, 19 Pieter-Steph du Toit, 20
Jean-Luc du Preez, 21 Francois Hougaard, 22 Frans Steyn, 23 Dillyn Leyds
15 Brice Dulin, 14 Yoann Huget, 13 Henry Chavancy, 12 Gaël Fickou, 11 Virimi Vakatawa, 10 Jules Plisson, 9 Maxime Machenaud, 8 Louis Picamoles, 7 Loann Goujon, 6 Yacouba Camara, 5 Yoann Maestri (captain), 4 Julien le Devedec, 3 Uini Atonio, 2 Clément Maynadier, 1 Jefferson Poirot
Substitutes: 16 Camille Chat, 17 Eddy Ben Arous, 18 Mohamed Boughanmi, 19 Bernard le Roux, 20 Kévin Gourdon, 21 Baptiste Serin, 22 Jean-Marc Doussain, 23 Vincent Rattez