Lionel Mapoe replaces James Kamana on left wing, while Hendrik Roodt receives a starting berth at lock in place of Stephan Greeff.
On the bench, Maties Varsity Cup star Grant Hattingh could make his Super Rugby debut.
Teams:
Lions:
15 Andries Coetzee, 14 Deon van Rensburg, 13 Jaco Taute, 12 Alwyn Hollenbach, 11 Lionel Mapoe, 10 Elton Jantjies, 9 Tian Meyer, 8 Joshua Strauss (captain), 7 Derick Minnie, 6 Cobus Grobbelaar, 5 Franco van der Merwe, 4 Hendrik Roodt, 3 Patric Cilliers, 2 Callie Visagie, 1 Caylib Oosthuizen
Substitutes: 16 Martin Bezuidenhout, 17 Jacobie Adriaans, 18 Grant Hattingh, 19 Christo le Roux, 20 Ross Cronje, 21 Butch James, 22 Michael Killian
Brumbies:
TBA