Cape Town - France's Jérôme Garcès will referee the Scotland v Springboks Test at Murrayfield in Edinburgh on Sunday.
Kick-off is at 17:00.
Both the Boks and Wales suffered at the hands of Ireland's Alain Rolland in their Test last weekend, and will welcome the sight of Garcès who took control of the Boks' recent Rugby Championship victory over Australia at Newlands in late September.
In other matches scheduled for the weekend, South Africa's Craig Joubert will be the man in the middle in the England v New Zealand clash at Twickenham.
Meanwhile, the world's most capped Test referee, South Africa's Jonathan Kaplan will be handling his 70th - and likely last - Test in Windhoek between Namibia and Kenya.
Saturday, November 16
Italy v Fiji at Stadio Zini, Cremona - 16:00
Referee: Leighton Hodges (Wales)
Assistant referees: Jaco Peyper (South Africa), Joaquin Montes (Uruguay)
Television match official: Eric Gauzins (France)
Wales v Argentina at Millennium Stadium, Cardiff - 16:30
Referee: John Lacey (Ireland)
Assistant referees: Steve Walsh (Australia), Lourens van der Merwe (South Africa)
Television match official: Simon McDowell (Ireland)
England v New Zealand Twickenham - 16:30
Referee: Craig Joubert (South Africa)
Assistant referees: Nigel Owens (Wales), Francisco Pastrana (Argentina)
Television match official: Gareth Simmonds (Wales)
Ireland v Australia at Aviva Stadium, Dublin - 19:45
Referee: Chris Pollock (New Zealand)
Assistant referees: Romain Poite (France), Stuart Berry (South Africa)
Television match official: Geoff Warren (England)
Sunday, November 17
Scotland v South Africa at Murrayfield, Edinburgh - 17:00
Referee: Jérôme Garcès (France)
Assistant referees: Pascal Gauzère (France), Dudley Phillips (Ireland)
Television match official: Marshall Kilgore (Ireland)