Cardiff - Warrick Gelant and Dan du Preez will get their first starts for the Springboks in the final Test of 2017, against Wales at the Principality Stadium in Cardiff on Saturday.
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The inclusion of the exciting Gelant is one of five changes to the starting line-up announced by Springbok coach Allister Coetzee on Thursday for the last match of the Outgoing Tour.
Gelant was impressive when he came on as second half replacement against Italy last week for his Springbok debut and has replaced Courtnall Skosan on the left wing for his first start.
There are four changes among the forwards. Steven Kitshoff replaces the experienced Tendai Mtawarira, who is suffering from a groin injury and not available for selection.
Malcolm Marx has shrugged off his shoulder problem and takes over the hooker duties from Bongi Mbonambi, who moves to the bench.
Siya Kolisi is back in the side after missing the Italy Test because of paternal leave, and he comes in for Francois Louw on the side of the scrum, while Du Preez will also earns his first start in the No 8 jersey as replacement for Duane Vermeulen.
Louw, Vermeulen and Franco Mostert (lock) are back at their overseas clubs and not available because this match falls outside the World Rugby Test window.
Meanwhile, the uncapped duo of Lukhanyo Am (centre) and Louis Schreuder (scrumhalf) will join Mbonambi on the bench as two of a number of changes among the replacements, with Uzair Cassiem, Oupa Mohoje and Ruan Dreyer also included in the in the match day squad.
Eben Etzebeth will captain the Springbok team for the 11th time this season, playing in his 67th international match for South Africa.
15 Leigh Halfpenny, 14 Hallam Amos, 13 Scott Williams, 12 Hadleigh Parkes, 11 Steff Evans, 10 Dan Biggar, 9 Aled Davies, 8 Taulupe Faletau, 7 Josh Navidi, 6 Aaron Shingler, 5 Alun Wyn Jones, 4 Cory Hill, 3 Scott Andrews, 2 Kristian Dacey, 1 Rob Evans
Substitutes: 16 Elliot Dee, 17 Wyn Jones, 18. Rhodri Jones, 19 Seb Davies, 20 Dan Lydiate, 21 Rhys Webb, 22 Rhys Patchell, 23 Owen Watkin
15 Andries Coetzee, 14 Dillyn Leyds, 13 Jesse Kriel, 12 Francois Venter, 11 Warrick Gelant, 10 Handre Pollard, 9 Ross Cronjé, 8 Dan du Preez, 7 Pieter-Steph du Toit, 6 Siya Kolisi, 5 Lood de Jager, 4 Eben Etzebeth, 3 Wilco Louw, 2 Malcolm Marx, 1 Steven Kitshoff
Substitutes: 16 Bongi Mbonambi, 17 Trevor Nyakane, 18 Ruan Dreyer, 19 Oupa Mohoje 20 Uzair Cassiem, 21 Louis Schreuder, 22 Elton Jantjies, 23 Lukhanyo Am