Rome - Italy coach Jacques Brunel included four uncapped players in his 32-man squad for the upcoming South Africa tour on Friday.
Earning their first international call-ups were hooker Andrea Manici, scrum-half Alberto Chillon, wing Leonardo Sarto and fly-half Alberto Di Bernardo.
Simone Favaro, Quintin Geldenhuys and Mirco Bergamasco are all injured and miss out.
Italy play the Springboks in Durban on June 8, Samoa in Nelspruit on June 15 and Scotland in Pretoria on June 22.
Matias Aguero, Martin Castrogiovanni, Lorenzo Cittadini, Alberto De Marchi, Michele Rizzo, Leonardo Ghiraldini, Davide Giazzon, Andrea Manici, Valerio Bernabo, Marco Bortolami, Joshua Furno, Antonio Pavanello, Robert Barbieri, Mauro Bergamasco, Francesco Minto, Sergio Parisse, Manoa Vosawai, Alessandro Zanni
Tobias Botes, Alberto Chillon, Edoardo Gori, Alberto Di Bernardo, Luciano Orquera, Gonzalo Canale, Gonzalo Garcia, Luca Morisi, Alberto Sgarbi, Tommaso Iannone, Andrea Masi, Luke McLean, Leonardo Sarto, Giovanbattista Venditti