London - Manu Tuilagi is set to make his first England start in more than four years after being named in Eddie Jones' run-on XV to play champions Ireland in the teams' Six Nations opener in Dublin on Saturday.
The injury-plagued Leicester centre got his chance after Ben Te'o was ruled out with a side strain.
Tuilagi last started a match for England in the third Test against New Zealand in June 2014.
Elliot Daly held off the challenge of Mike Brown to remain at fullback for the Aviva Stadium clash when Jones announced his match-day 23 on Thursday.
Meanwhile, Jones handed a recall to Jack Nowell. Having spoken about the possibility of converting the Exeter flyer into a flank, the Australian coach selected him in his usual wing position.
But there is no doubt that England will want the defensively strong Nowell to help negate Grand Slam champions Ireland's threat at the ruck.
15 Robbie Henshaw; 14 Keith Earls, 13 Garry Ringrose, 12 Bundee Aki, 11 Jacob Stockdale; 10 Johnny Sexton, 9 Conor Murray; 8 CJ Stander, 7 Josh van der Flier, 6 Peter O'Mahony; 5 James Ryan, 4 Devin Toner; 3 Tadhg Furlong, 2 Rory Best (captain), 1 Cian Healy
Substitutes: 16 Sean Cronin, 17 Dave Kilcoyne, 18 Andrew Porter, 19 Quinn Roux, 20 Sean O'Brien, 21 John Cooney, 22 Joey Carbery, 23 Jordan Larmour
15 Elliot Daly, 14 Jonny May, 13 Henry Slade, 12 Manu Tuilagi, 11 Jack Nowell, 10 Owen Farrell (captain), 9 Ben Youngs, 8 Billy Vunipola, 7 Tom Curry, 6 Mark Wilson, 5 George Kruis, 4 Maro Itoje, 3 Kyle Sinckler, 2 Jamie George, 1 Mako Vunipola
Substitutes: 16 Luke Cowan-Dickie, 17 Ellis Genge, 18 Harry Williams, 19 Courtney Lawes, 20 Nathan Hughes, 21 Dan Robson, 22 George Ford, 23 Chris Ashton