Milan - Italy coach Conor O'Shea made four changes to his side from last weekend's Six Nations defeat by France for Saturday's final match of the tournament against Scotland.
Italy are guaranteed the wooden spoon after losing all four of their matches and travel to Murrayfield bidding to avoid a second straight pointless campaign.
Centre Michele Campagnaro is recovering from a shoulder injury and replaced by Tommaso Benvenuti.
Maxime Mbanda starts in the third row ahead of Simone Favaro, as in last month's 36-15 defeat to England, while in the second row Dries Van Schalkwyk cedes his place to George Biagi.
Ornel Gega will occupy the post of hooker with Leonardo Ghiraldini starting on the bench.
15 Edoardo Padovani; 14 Angelo Esposito, 13 Tommaso Benvenuti, 12 Luke McLean, 11 Giovanbattista Venditti; 10 Carlo Canna, 9 Edoardo Gori; 8 Sergio Parisse (captain), 7 Abraham Steyn, 6 Maxime Mbanda; 5 George Biagi, 4 Marco Fuser; 3 Lorenzo Cittadini, 2 Ornel Gega, 1 Andrea Lovotti.
Substitutes: 16 Leonardo Ghiraldini, 17 Sami Panico, 18 Dario Chistolini, 19 Dries Van Schalkwyk, 20 Federico Ruzza, 21 Francesco Minto, 22 Marcello Violi, 23 Luca Sperandio.
15 Stuart Hogg; 14 Tommy Seymour, 13 Huw Jones, 12 Alex Dunbar, 11 Tim Visser; 10 Finn Russell, 9 Ali Price; 8 Ryan Wilson, 7 Hamish Watson, 6 John Barclay (captain); 5 Jonny Gray, 4 Richie Gray; 3 Zander Fagerson, 2 Ross Ford, 1 Gordon Reid
Substitutes: 16 Fraser Brown, 17 Allan Dell, 18 Simon Berghan, 19 Tim Swinson, 20 Cornell du Preez, 21 Henry Pyrgos, 22 Duncan Weir, 23 Matt Scott