London - Winger Sean Maitland and flanker Blair Cowan have both pulled out of Scotland's squad for Saturday's Six Nations match against Italy in Rome due to injuries.
Maitland missed the 27-23 defeat to Wales with a hamstring strain while Cowan lasted just 10 minutes of the match in Cardiff after suffering a concussion shortly after making his introduction as a second-half substitute.
Neither of the London Irish pair has recovered in time to face the Italians. Both sides have lost their two opening games in the tournament.
Also dropping out of head coach Vern Cotter's training squad are Glasgow trio Alex Allan, Chris Fusaro - both with head knocks - and Pat MacArthur, who is ruled out with groin and thigh issues.
However, Cotter has been boosted by the return to fitness of Harlequins wing Tim Visser and Warriors centre Peter Horne after both men completed their recoveries from hamstring and foot injuries.
Cotter has also called up Glasgow's scrumhalf Grayson Hart, flankers Rob Harley and Ryan Wilson as well as Edinburgh's uncapped hooker George Turner and back-row Hamish Watson to their training camp at Murrayfield.