Dublin - Garry Ringrose and Devin Toner will miss Ireland's Six Nations clash in Scotland on Saturday due to injury, the Irish Rugby Football Union announced on Tuesday.
Leinster centre Ringrose picked up a hamstring complaint and Leinster lock Toner aggravated an existing ankle problem in Saturday's 32-20 Dublin defeat by England.
Wing Keith Earls, who was replaced at half-time with a hip issue, trained on Tuesday, but Ireland will be without CJ Stander, who misses the match with a facial injury.