London - England have suffered a double setback after both Nathan Hughes and Courtney Lawes were ruled out of their concluding Six Nations match against Ireland at Twickenham.
The back-row forwards suffered knee injuries during England's 22-16 defeat by France in Paris on Saturday, a result that ended English hopes of a third successive Six Nations title under Australian coach Eddie Jones.
Both Hughes and Lawes were omitted from a 32-man training squad announced on Sunday ahead of England's tournament finale at home to Ireland on March 17.
Hughes limped off in the 24th minute at the Stade de France after taking a heavy blow to his left knee, but Lawes did manage to finish the match.
Both players are due to undergo scans on Monday.
Ireland were crowned champions on Saturday, their bonus-point win at home to Scotland combined with England's loss giving them an unassailable lead at the top of the table.
The Irish will now look to complete just their third Five/Six Nations Grand Slam by beating England, having denied Jones' men a Championship clean sweep in Dublin last season.
Mike Brown (Harlequins), Danny Care
(Harlequins), Elliot Daly (Wasps), Nathan Earle (Saracens), Owen Farrell
(Saracens), George Ford (Leicester Tigers), Jonathan Joseph (Bath
Rugby), Alex Lozowski (Saracens), Jonny May (Leicester Tigers), Henry
Slade (Exeter Chiefs), Marcus Smith (Harlequins)*, Denny Solomona (Sale
Sharks), Ben Te’o (Worcester Warriors), Anthony Watson (Bath Rugby),
Richard Wigglesworth (Saracens)
Don Armand (Exeter Chiefs), Dan Cole
(Leicester Tigers), Luke Cowan-Dickie (Exeter Chiefs), Charlie Ewels
(Bath Rugby), Jamie George (Saracens), Dylan Hartley (Northampton
Saints), James Haskell (Wasps), Alec Hepburn (Exeter Chiefs), Nick
Isiekwe (Saracens), Maro Itoje (Saracens), George Kruis (Saracens), Joe
Launchbury (Wasps), Joe Marler (Harlequins), Chris Robshaw (Harlequins),
Sam Simmonds (Exeter Chiefs), Kyle Sinckler (Harlequins), Mako Vunipola
* Apprentice player